AI Article Synopsis
- Existing vaccines for hepatitis B are effective, but the virus remains a significant health issue due to challenges like cccDNA and potential reinfection.
- RNA interference (RNAi) is being explored as a promising treatment strategy for chronic hepatitis B, offering a new approach to silence the virus.
- A review analyzed 76,949 studies, narrowing it down to 226 key reports, highlighting RNAi's potential while calling for more research to bridge the gap between laboratory findings and real-world treatment applications.
Article Abstract
Background: Despite an existing safe and effective vaccine for hepatitis B virus (HBV), it is still a major public health concern. Nowadays, several drugs are used to treat chronic hepatitis B; however, full healing remains controversial. The viral covalently closed circular DNA (cccDNA) formed by HBV forms a major challenge in its treatment, as does the ability of HBV to integrate itself into the host genome, which enables infection reactivation. Interfering RNA (RNAi) is a gene-silencing post-transcriptional mechanism which forms as a promising alternative to treat chronic hepatitis B. The aim of the present review is to assess the evolution of hepatitis B treatment approaches based on using RNA interference.
Methods: Data published between 2016 and 2023 in scientific databases (PubMed, PMC, LILACS, and Bireme) were assessed.
Results: In total, 76,949 articles were initially identified and quality-checked, and 226 eligible reports were analyzed in depth. The main genomic targets, delivery systems, and major HBV therapy innovations are discussed in this review. This review reinforces the therapeutic potential of RNAi and identifies the need for conducting further studies to fill the remaining gaps between bench and clinical practice.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11598949 | PMC |
| http://dx.doi.org/10.3390/v16111710 | DOI Listing |
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