The 31P NMR of aqueous [Dy(P3O10)2]7- demonstrates that it is in slow exchange with P3O5-10 on the NMR time scale. In the presence of tissue, [Dy(P3O10)2]7- decomposes to PO4 with an accompanying slow change of the tissue 23Na NMR of extracellular Na+ ion in several NMR distinguishable extracellular sites.
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http://dx.doi.org/10.1002/mrm.1910030125 | DOI Listing |
J Phys Chem A
January 2025
Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario K7L 3N6, Canada.
We report a new NMR method for treating two-site chemical exchange involving half-integer quadrupolar nuclei in a solution. The new method was experimentally verified with extensive Na ( = 3/2), K ( = 3/2), and Rb ( = 3/2) NMR results from alkali metal ions (Na, K, and Rb) in a solution over a wide range of molecular tumbling conditions. In the fast-motion limit, all allowed single-quantum NMR transitions for a particular quadrupolar nucleus are degenerate giving rise to one Lorentzian signal.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Solid State Chemistry, Faculty of Chemical Technology, University of Chemistry and Technology, Technická 5, 16628 Prague, Czech Republic.
The most commonly used homogeneous catalyst for fatty acid esterification is a corrosive sulphuric acid. However, this requires costly investment in non-corrosive equipment, presents a safety risk, is time consuming, and increases effluent generation. In this study, inorganic 3D heteroborane cluster strong acids are employed for the first time as homogeneous catalysts.
View Article and Find Full Text PDFNMR Biomed
February 2025
Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA.
Cellular metabolism is inextricably linked to transmembrane levels of proton (H), sodium (Na), and potassium (K) ions. Although reduced sodium-potassium pump (Na-K ATPase) activity in tumors directly disturbs transmembrane Na and K levels, this dysfunction is a result of upregulated aerobic glycolysis generating excessive cytosolic H (and lactate) which are extruded to acidify the interstitial space. These oncogene-directed metabolic changes, affecting intracellular Na and H, can be further exacerbated by upregulation of ion exchangers/transporters.
View Article and Find Full Text PDFJ Magn Reson
November 2024
Sir Peter Mansfield Imaging Centre, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom.
Double-quantum filtered Na NMR experiments with one or two "magic angle" (54.7°) pulses in the filter step are widely used for selective observation of sodium ions that are interacting with ordered biological structures ("ordered sodium") and hence exhibit a distribution of quadrupolar splittings in their NMR spectrum. This approach has recently been extended to Na MRI where the conventional experiment has been modified, omitting the 180° pulse to reduce the absorption of radiofrequency energy during human studies.
View Article and Find Full Text PDFArXiv
December 2024
Center for Biomedical Imaging, Department of Radiology, NYU Grossman School of Medicine, New York, NY, USA.
We developed a new sodium magnetic resonance fingerprinting (Na MRF) method for the simultaneous mapping of and sodium density with built-in (radiofrequency transmission inhomogeneities) and corrections (frequency offsets). We based our Na MRF implementation on a 3D FLORET sequence with 23 radiofrequency pulses. To capture the complex spin dynamics of the Na nucleus, the fingerprint dictionary was simulated using the irreducible spherical tensor operators formalism.
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