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Polyhydroxyalkanoates: Medical Applications and Potential for Use in Dentistry. | LitMetric

Polyhydroxyalkanoates: Medical Applications and Potential for Use in Dentistry.

Materials (Basel)

Egas Moniz School of Health & Science, Campus Universitário, Quinta da Granja, 2829-511 Caparica, Portugal.

Published: November 2024

AI Article Synopsis

  • * They are produced by microorganisms and have diverse applications, especially in biomedicine, including uses in vascular grafts, tissue regeneration, and drug delivery systems.
  • * The review aims to explore the medical and dental uses of PHAs, highlighting their benefits and limitations in healthcare innovations.

Article Abstract

Polyhydroxyalkanoates (PHAs) are promising biopolymers as an alternative to traditional synthetic polymers due to their biodegradability and biocompatibility. The PHA market is blooming in response to the growing demand for biodegradable and environmentally friendly plastics. These biopolyesters are produced and degraded by a variety of microorganisms, making them environmentally friendly, while offering benefits such as biocompatibility (when adequately processed) and biodegradability. Their versatility extends to various areas, from biomedicine to agriculture and composite materials, where they pave the way for significative innovations. In the field of regenerative medicine, some PHAs have key applications, namely in vascular grafts, oral tissue regeneration, and development of self-healing polymers. In addition, PHAs have the potential to be used in the creation of dental implant materials and dental medical devices. PHAs can also be used to encapsulate hydrophobic drugs, providing an approach for more targeted and effective treatments. To summarize, PHAs open new perspectives in the field of medicine by improving drug delivery and offering ecologically biocompatible solutions for medical devices. The aim of this review is to present the medical and dental applications of PHA, their advantages, disadvantages, and indications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595952PMC
http://dx.doi.org/10.3390/ma17225415DOI Listing

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