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The Effect of Insomnia on the Outcomes of Physical Therapy in Patients with Cervical and Lumbar Pain in Clinical Practice. | LitMetric

AI Article Synopsis

  • The study aims to compare physical therapy outcomes between patients with chronic back pain who have insomnia and those without insomnia, over a two-week treatment period in a clinical setting.
  • It involved 38 patients with insomnia (experimental group) and 41 without (control group) who completed various questionnaires to measure pain, insomnia severity, and quality of life, along with blood tests for neurotropic biomarkers.
  • Results showed that while pain levels remained higher for the insomnia group at the end of treatment, the control group had a better relative treatment response; however, the insomnia group's quality of life improved significantly more, indicating a substantial treatment benefit despite initial higher neuronal damage markers in their blood.

Article Abstract

: The objective of the study is to determine whether there is a difference in physical therapy outcomes in patients with cervical and/or lumbar pain who have insomnia compared to patients without insomnia during a two-week period of active treatment under the conditions of routine clinical practice. : The study population consisted of two groups of subjects with chronic back pain, a group with insomnia ("case") with a total of 38 subjects and a control group without insomnia ("control") with a total of 41 subjects, who filled out a set of measurement questionnaires: the McGill Pain Questionnaire and its short form (SF-MPQ), the Insomnia Severity Index (ISI) and the European Quality of Life Questionnaire of Life (Euro Qol; EQ-5D). Determination of the biomarkers of structural damage to the nervous tissue, neurofilament polypeptide (NEF-neurofilament polypeptide), neuron-specific enolase (NSE-neuron-specific enolase) and protein S100B was performed by measuring their concentrations in the blood using the ELISA method (enzyme immunosorbent assay). Statistical analysis of the collected data included a descriptive analysis, hypothesis testing methods and univariable and multivariable regression models. : At the end of the treatment visits, the level of pain remained higher in some subjects of the experimental group, but the statistical significance of the baseline difference disappeared because of the higher relative treatment response in the controls. Measured with a visual analogue scale, the treatment improved the patients' quality of life much more in experimental than control subjects, as is proven by the statistically significant difference for the percent change from baseline (~31% vs. ~14%). At baseline, all three neurotropic biomarkers had significantly higher serum values in the subjects of the experimental group than in the control patients, which suggested more damage to the neuronal structures. During the treatment course, their serum concentrations decreased, from 36% to 95%, but for S100B, unlike NES and NEF, there was no statistically significant difference between the study groups at the end of the treatment visits. : The results of the study have immediate scientific and practical significance because they contribute to new knowledge about the place and role of insomnia in patients with cervical and/or lumbar pain who are treated with physical medicine methods in the conditions of routine clinical practice. The treatment of insomnia should be an indispensable part of therapeutic treatment for patients with back pain.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11596617PMC
http://dx.doi.org/10.3390/medicina60111873DOI Listing

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