Loss Promotes Chronic Hepatic Inflammation and Metabolic Dysregulation.

CD161, encoded by the gene, is an inhibitory receptor expresses on various immune cell and has gained attention in immune checkpoint research. In recent studies, has been found to be one of the potential markers of liver diseases such as cirrhosis. Therefore, it will be important to understand what process involved in the liver for the prevention of liver diseases. We compared mice with wild-type controls by routine blood analysis and RNA-seq, and additionally performed H&E staining and qPCR to validate the differentially expressed genes (DEGs). mice had fewer lymphocytes compared to the wild-type mice. A transcriptomic analysis showed that loss causes the upregulation of immune-related genes and pathways like NOD-like receptor and p53 signaling, while causing the downregulation of lipid metabolism-related genes. A protein interaction analysis indicated a potential cancer risk under chronic inflammation. Histological examination with H&E staining reveals an inflammatory response around the central venous vessels in the liver tissue of the mice. : We conclude that knockout disrupts the immune and metabolic functions in the liver, which may possibly lead to chronic inflammation and malignancy risks. These findings highlight the role of in hepatic health.