AI Article Synopsis
- The study investigates how dark deprivation influences liver health and circadian rhythms when exposed to carbon tetrachloride (CCl), a known hepatotoxic agent.
- While much is known about CCl's effects on the liver, research on its impact within the context of circadian rhythms is limited, and many studies focus on isolated periods rather than the overall rhythm.
- Findings suggest that dark deprivation leads to more severe structural and functional liver changes due to reduced melatonin levels, indicating the need for further research on the role of melatonin in these processes.
Article Abstract
The effect of dark deprivation on the morphofunctional state and rhythmostasis of the liver under CCl toxic exposure has been studied. The relevance of this study is due to the fact that the hepatotoxic effect of carbon tetrachloride on the liver is well studied, but there are very few data on the relationship between CCl intoxication and circadian biorhythms, and most of the studies consider the susceptibility of the organism in general and of the liver in particular to the influence of CCl in some separate periods of the rhythm, but not the influence of this chemical agent on the structure of the whole rhythm. In addition, earlier studies indicate that light disturbance causes certain changes in the morphofunctional state of the liver and the structure of the circadian rhythm of a number of parameters. As a result of this study, we found that the effect of CCl in conditions of prolonged dark deprivation causes more significant structural and functional changes in hepatocytes, as well as leading to significant changes in the circadian rhythms of a number of parameters, which was not observed in the action of CCl as a monofactor. We assume that the severity of structural and functional changes is due to the light-induced deficiency of melatonin, which has hepatoprotective properties. Thus, the mechanisms of CCl action on CRs under conditions of light regime violations leave a large number of questions requiring further study, including the role of melatonin in these processes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11594381 | PMC |
| http://dx.doi.org/10.3390/ijms252212476 | DOI Listing |
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