AI Article Synopsis
- The study focuses on creating new fluorosulfate derivatives of 1,4-naphthoquinone through the SuFEx reaction and evaluates their anticancer effects on various cancer cell lines, showing they are more cytotoxic than Cisplatin.
- The electronic structures of these compounds were analyzed using Density Functional Theory (DFT) to understand their cytotoxic properties.
- A method using an impregnated graphite electrode (IMGE) was developed for detecting these compounds, and their electrochemical behavior was examined using cyclic voltammetry.
Article Abstract
This study presents the synthesis of new fluorosulfate derivatives of 1,4-naphthoquinone by the SuFEx reaction. Anticancer properties of obtained compounds were studied on PC-3 (prostate adenocarcinoma), SKOV-3 (ovarian cancer), MCF-7 (breast cancer), and Jurkat cell lines. All the studied compounds showed higher cytotoxic effects than Cisplatin. The DFT method was applied to determine the electronic structure characteristics of 1,4-naphthoquinone derivatives associated with cytotoxicity. A method of determination of 2,3-dichloro-1,4-naphthoquinone (), 3-chloro-2-((4-hydroxyphenylamino)-1,4-naphthoquinone (), and 4-((3-chloro-1,4-naphthoquinon-2-yl)amino)phenyl fluorosulfate () in a pharmaceutical substance using an impregnated graphite electrode (IMGE) was developed. The morphology of the IMGE surface was studied using scanning electron microscopy (SEM). The electrochemical behavior of , , and was studied by cyclic voltammetry (CV) in 0.1 M NaClO (96% ethanol solution) at pH 4.0 in a potential range from -1 to +1.2 V. Electrochemical redox mechanisms for the investigated compounds were proposed based on the determining main features of the electrochemical processes. Calibration curves were obtained by linear scan voltammetry in the first derivative mode (LSVFD) with the detection limit (LOD) 7.2 × 10 mol·L for , 8 × 10 mol·L for , and 8.6 × 10 mol·L for , respectively.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11595164 | PMC |
| http://dx.doi.org/10.3390/ijms252212245 | DOI Listing |
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