AI Article Synopsis
- The study aimed to assess how human subjects react to elevated pressures of helium and nitrogen, focusing on inflammatory and oxidative stress responses.
- Both gases activated neutrophils and led to slight increases in inflammatory markers and urinary IL-6, alongside a decrease in plasma gelsolin, indicating an inflammatory response.
- The results suggest that typical diving gas exposure can trigger inflammation, which might contribute to decompression sickness, while the mixed oxidative stress responses imply complex interactions within the body's systems.
Article Abstract
The goal of this study was to evaluate inflammatory and oxidative stress responses in human subjects (9 females and 15 males) (age [29.6 ± 11.5 years old (mean ± SD)], height [172.0 ± 10.05 cm], and weight [67.8 ± 12.4 kg]) exposed to 1.45 ATA of helium (He) or nitrogen (N) without concurrent hyperoxia. We hypothesized that elevated gas pressures would elicit an inflammatory response concurrent with oxidative stress. Consistent with ex vivo studies, both gasses elicited neutrophil activation, small elevations in microparticles (MPs) and increases in intra-MP interleukin (IL)-1β and inflammatory nitric oxide synthase, and an increase in urinary IL-6 concurrent with a marked reduction in plasma gelsolin. Mixed responses indictive of oxidative stress, with some biomarker elevations but little change in others and a decrease in some, were observed. Overall, these results demonstrate that exposure to typical diving gasses at a mildly elevated partial pressure will initiate inflammatory responses, which may play a significant role in decompression sickness (DCS). The complex pattern of oxidative stress responses may be indicative of competing systemic reactions and sampling different body fluids.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11593890 | PMC |
| http://dx.doi.org/10.3390/ijms252212067 | DOI Listing |
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