Background: Hypofunction of the glutamate system in the brain is one of the pathophysiological hypotheses for schizophrenia. Accumulating animal and clinical studies show that sarcosine (N-methylglycine), a glycine transporter-1 inhibitor, is effective in ameliorating the negative and cognitive symptoms of schizophrenia. The aims of the present study were to observe the effects of sarcosine on neuronal activity in the dorsal CA1 (dCA1) hippocampal neurons within an NMDA receptor hypofunction model induced by MK801.
Methods: We applied in vivo calcium imaging to observe the dynamics of fluorescence from the dCA1 hippocampal neurons when the mice were exploring in an open field. Using this tool, we directly measured and compared neuronal properties between sarcosine-treated and untreated mice. At the same time, the physiological function of the neurons was also quantified by measuring their place fields.
Results: Our data demonstrated that MK-801 (0.2 mg/kg) diminished the fluorescence intensity of dCA1 neurons that had been genetically modified with a calcium indicator. MK-801 also significantly increased the correlation coefficient between the fluorescence dynamics of pairs of cells, a feature that may be linked to the symptom of disorganization in human patients with schizophrenia. The spatial correlations of place fields in the mice were impaired by MK-801 as well. Injected sarcosine (500 mg or 1000 mg/kg) significantly alleviated the abovementioned abnormalities.
Conclusions: Our data provide evidence to support the use of sarcosine to alleviate symptoms of schizophrenia, especially hippocampus-related functions.
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http://dx.doi.org/10.3390/brainsci14111150 | DOI Listing |
ACS Appl Mater Interfaces
December 2024
Department of Chemical Engineering, Guangdong Technion - Israel Institute of Technology, 241 Daxue Road, Shantou, Guangdong 515063, China.
Facilitated transport membranes (FTMs) with an ultraselective layer prepared from amine-rich polyvinylamine (PVAm)/2-(1-piperazinyl)ethylamine salt of sarcosine (PZEA-Sar) (denoted by PM) and an amorphous dendritic cross-linked network of PVAm-functionalized poly(ethylene glycol)diglycidyl ether (PEGDGE) (named PP) were designed for CO separations. The developed membranes expedited CO transport over N through the synergistic effect from the induced CO-philic ethylene oxide groups and highly hydrophilic and polar hydroxyl groups together with the low-crystallinity PP networks, which offer a high diffusion rate for CO-amine complexes through the membrane and stabilize small molecular mobile carriers via hydrogen bonding. The best (PM/PP-10)/polysulfone (PSf) composite membranes achieved a superior CO/N selectivity of 230 (4.
View Article and Find Full Text PDFBrain Sci
November 2024
Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.
Background: Hypofunction of the glutamate system in the brain is one of the pathophysiological hypotheses for schizophrenia. Accumulating animal and clinical studies show that sarcosine (N-methylglycine), a glycine transporter-1 inhibitor, is effective in ameliorating the negative and cognitive symptoms of schizophrenia. The aims of the present study were to observe the effects of sarcosine on neuronal activity in the dorsal CA1 (dCA1) hippocampal neurons within an NMDA receptor hypofunction model induced by MK801.
View Article and Find Full Text PDFFoods
October 2024
Livestock Product Processing and Engineering Technology Research Center of Yunnan Province, Yunnan Agricultural University, Kunming 650201, China.
Adding edible fungal polysaccharides to animal diets improves growth performance, meat quality, intestinal health, and immunity without adverse effects. This study aimed to evaluate the impact of polysaccharide (PCP, including PCP250, PCP500, PCP750, and PCP1000 mg/kg) on the growth performance, meat quality, and microbial composition of Arbor Acre (AA) broilers (total 180) by metabolomics and high-throughput sequencing. The results showed that adding PCP enhanced chicken meat tenderness, redness (*), and water retention and raised essential amino acids and flavor amino acids (such as umami and sweet amino acids) content.
View Article and Find Full Text PDFSci Total Environ
October 2023
Department of Environmental Biotechnology, Helmholtz Centre for Environmental Research - UFZ, Permoserstr. 15, 04318 Leipzig, Germany.. Electronic address:
Widely-used glyphosate may produce aminomethylphosphonic acid (AMPA), glycine and sarcosine. To date, little is known about effects of these degradation products on soil microorganisms and their potential degraders. Here, we incubated a soil spiked either with 2-C-glyphosate, C-AMPA, C-sarcosine or C-glycine for 75 days.
View Article and Find Full Text PDFJ Colloid Interface Sci
February 2025
Institute of Polymer Science and Engineering, Hebei University of Technology, 5340 Siping Road, Tianjin 300401, China. Electronic address:
Sarcosine plays a key role in screening for early prostate cancer. However, the several already reported peroxidase mimics immobilized with sarcosine oxidase (SOX) utilized to detect uriary sarcosine still have some limitations such as complex synthesis process, using of expensive heavy metals to mimic enzyme activity and long color development time. Herein, an inexpensive peroxidase-like 2D Fe/Co-MOF nanosheet was prepared by a simple solvent modulation method.
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