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Background: Essential workers, including those working in healthcare and education, are at higher risk of exposure to communicable diseases, including SARS-CoV-2. Reducing the rates of infection is important for their personal health and for the ongoing safe operation of essential services.
Methods: Data from participants in two prospective cohort studies who tested positive for SARS-CoV-2 in 2020 through 2023 were used to determine whether vaccination against SARS-CoV-2 is associated with the severity of symptoms in working-age adults.
Results: SARS-CoV-2-positive tests (N = 3757) were reported by 3093 participants (mean: 1.2 per person); 1229 (33%) illnesses did not interfere with regular activities, 1926 (51%) made participants too unwell for regular activities, and 602 (16%) required participant bed rest. Compared with vaccine receipt more than 12 months earlier, receipt within six months of an infection was associated with lower risk ratios for more severe illness (too unwell: 0.69 and bed rest: 0.67) compared with being able to conduct regular activities. More recent vaccination was also associated with lower odds reporting of systemic symptoms (fever, myalgia, arthralgia) and fewer solicited symptoms.
Conclusion: Staying current with COVID-19 vaccinations should continue to be recommended since receiving a recent immunization lessened the severity of illness. Also, as symptoms of COVID-19 are now largely similar to other respiratory viruses, practitioners need to use this evidence to inform diagnostic testing and return-to-work policies.
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http://dx.doi.org/10.3390/ijerph21111501 | DOI Listing |
Front Oncol
December 2024
Department of Medical Oncology, International Ward, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, China.
Background: ROS1, a member of the sevenless subfamily of tyrosine kinase insulin receptors, promotes tumor cell survival, proliferation, and metastasis by activating the JAK/STAT, PI3K/AKT, and MAPK/ERK pathways. It only accounts for about 2% of total NSCLC cases. No cases of acquired ROS-1 rearrangement have been reported worldwide.
View Article and Find Full Text PDFCureus
November 2024
Internal Medicine - Medicina 2, Unidade Local de Saúde do Alto Minho - Hospital Conde de Bertiandos, Ponte de Lima, PRT.
Effective communication is crucial in multidisciplinary teams (MDTs) within palliative care, where patient needs can be complex and multifaceted. This article examines the significance of communication in promoting collaborative, patient-centered care while addressing challenges such as professional jargon, hierarchical barriers, and the emotional strain associated with end-of-life care. Leadership plays a vital role in creating an environment of open dialogue, reducing hierarchical dynamics, facilitating conflict resolution, and supporting the emotional well-being of team members.
View Article and Find Full Text PDFFront Pharmacol
December 2024
Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Cisplatin binds to serum albumin in the body at a rate of 90%, and high levels of free cisplatin are a significant cause of its nephrotoxicity. Therefore, hypoalbuminemia theoretically poses a significant risk factor for cisplatin-induced acute kidney injury (CIA) and can be easily corrected. However, existing research results are inconsistent.
View Article and Find Full Text PDFFront Sports Act Living
December 2024
Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.
Regular physical activity can prevent various physical and mental illnesses or improve their prognosis. However, only about half of the German population meets the WHO recommendations for physical activity. The aim of this study was to identify factors that influence engagement in regular exercise and could help increase physical activity levels in the general population.
View Article and Find Full Text PDFLancet Digit Health
January 2025
Biomedical Engineering Department, Duke University, Durham, NC, USA; Biostatistics and Bioinformatics Department, Duke University, Durham, NC, USA. Electronic address:
Background: Longitudinal digital health studies combine passively collected information from digital devices, such as commercial wearable devices, and actively contributed data, such as surveys, from participants. Although the use of smartphones and access to the internet supports the development of these studies, challenges exist in collecting representative data due to low adherence and retention. We aimed to identify key factors related to adherence and retention in digital health studies and develop a methodology to identify factors that are associated with and might affect study participant engagement.
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