AI Article Synopsis
- PTSD is a serious condition often characterized by neuroinflammation, and its prevalence is notably higher in women, with studies suggesting that CBD might be a viable treatment option.
- In an experiment involving female rats, those subjected to severe stress experienced PTSD-like symptoms; however, daily CBD injections significantly reversed these impairments and improved overall behavior.
- Analysis of brain tissues revealed that CBD not only reduced anxiety and fear responses but also diminished neuroinflammation in specific brain areas, highlighting its potential as a therapeutic for PTSD.
Article Abstract
Post-traumatic stress disorder (PTSD) is a debilitating neuropsychiatric condition closely linked to neuroinflammation, with a higher prevalence in women. Cannabidiol (CBD), a non-psychoactive cannabinoid, has shown promise as a potential treatment for PTSD. In this study, we used a PTSD model in which female rats were subjected to a severe foot shock followed by contextual situational reminders (SRs). Testing was conducted one month after exposure. The rats received daily CBD injections for three weeks during the SRs, from days 7 to 28. Two days after the final SR, the rats underwent five extinction trials, followed by the forced swim test (FST). After a five-day rest period, the rats were sacrificed, and brain tissues from the medial prefrontal cortex (mPFC) and ventral subiculum (vSUB) were analyzed for inflammatory markers. Chronic CBD treatment reversed impairments in fear extinction caused by shock and SR. It also reduced learned helplessness in the FST and decreased the upregulation of mPFC- induced by shock and SRs. Additionally, exposure to shock and SRs downregulated mPFC- while upregulating vSUB- CBD treatment further downregulated expression in the vSUB compared to the vehicle groups. Our findings show that CBD effectively inhibited the development of PTSD-like behaviors and suppressed neuroinflammation in the mPFC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591736 | PMC |
| http://dx.doi.org/10.3390/biom14111384 | DOI Listing |
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