Evaluation of Recovery Time and Quality After Two Different Post-Operative Doses of Medetomidine in Spanish Purebred Horses Anaesthetized with Medetomidine-Isoflurane Partial Intravenous Anaesthesia.

Recovery from general anaesthesia is risky in horses. Alpha-agonist administration after anaesthesia enhances the quality of recovery but may prolong this phase. Recovery time and quality were investigated after medetomidine administration at the end of general anaesthesia in a prospective, randomised, masked and clinical study. Horses underwent medetomidine-isoflurane partial intravenous anaesthesia. Medetomidine (0.5 or 1 µg/kg) IV was administered just after isoflurane was discontinued. The duration of different recovery phases and the number of attempts were recorded. A composite scale (from 1-excellent to 6-accident) was used for quality assessment. Mann-Whitney U-test was performed ( < 0.05). Twenty-seven horses per group were included. Results for 0.5 and 1 µg/kg groups were as follows: lateral recumbency time: 35 (24-45) and 43 (35-55) minutes; sternal recumbency time: 6 (3-15) and 5 (2-15) minutes; total recovery time: 47 (40-59) and 49 (42-62) minutes; number of attempts to sternal: 1 (1-1) and 1 (1-2) and to standing: 1 (1-3) and 1 (1-2); and, quality: 2 (1-2) and 2 (1-2), respectively. No significant differences between the groups were found. Medetomidine 0.5 µg/kg dose did not decrease the recovery time but maintained the recovery quality.