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(CAG) Microsatellite and c.444T>G (p.Asp148Glu) Polymorphisms as Independent Prognostic Biomarkers in Prostate Cancer: Insights from an Argentinian Cohort. | LitMetric
Background/objectives : Prostate cancer (PCa) is the leading malignancy and the third most common cause of cancer-related death in Argentinian men. Predicting outcomes in localized PCa remains difficult due to tumor heterogeneity. In this study, we assessed the impact of (CAG) and c.444T>G polymorphisms on biochemical relapse in Argentine patients with localized PCa.Methods : We genotyped blood samples from 123 PCa patients for (CAG) and p.Asp148Glu (c.444T>G) polymorphisms. Associations with clinicopathological parameters and biochemical relapse-free survival (BRFS) were assessed.Results : (CAG) was associated with a family history of breast/ovarian cancer ( = 0.0469). The combination of (CAG) and c.444TT/GG correlated with a 2.89 times higher risk of biochemical relapse (log-rank = 0.006). Multivariable analysis confirmed and polymorphisms as independent predictors of biochemical relapse (HR = 3.95, = 0.002). In patients with PSA levels <10 ng/mL, combined (CAG) and c.444TT/GG genotypes were significantly associated with an increased risk of biochemical relapse (HR = 2.61, = 0.044). Multivariable analysis confirmed the prognostic significance of these genotypes (HR = 3.44, = 0.02).Conclusions : This study has identified (CAG) and c.444T>G polymorphisms as independent predictors of PCa relapse in Argentinian patients, suggesting their potential use in improving prognostic models.
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