AI Article Synopsis

  • * Current treatments for melanoma brain metastases include stereotactic radiosurgery (SRS) and immunotherapy, particularly immune checkpoint inhibitors (ICIs), which show improved effectiveness over traditional methods.
  • * Ongoing research is focused on combining various immunotherapies with radiotherapies to enhance treatment results and reduce side effects, emphasizing the need for future studies on therapy sequencing.

Article Abstract

Melanoma remains a formidable challenge in oncology, causing the majority of skin cancer deaths in the United States, with brain metastases contributing substantially to this mortality. This paper reviews the current therapeutic strategies for melanoma brain metastases, with a focus on delayed and concurrent stereotactic radiosurgery (SRS). While surgery and traditional chemotherapy offer limited efficacy, recent advances in immunotherapy, particularly immune checkpoint inhibitors (ICIs), have played a major role in the advancement and improved efficacy of the treatment of cancers, including brain metastases. Recent studies indicate that monotherapy with ICIs may lead to a higher median overall survival compared to historical benchmarks, potentially allowing patients to delay radiosurgery. Other studies have found that combining SRS with ICIs demonstrates promise, with results indicating improved intracranial control. Ongoing clinical trials explore novel combinations of immunotherapies and radiotherapies, aiming to optimize treatment outcomes while minimizing adverse effects. As treatment options expand, future studies will be necessary to understand the interplay between therapies and their optimal sequencing to improve patient outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11591981PMC
http://dx.doi.org/10.3390/cancers16223733DOI Listing

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