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The Use of Cangrelor in Cardiogenic Shock: Insights from the CAMEO Registry.
J Card Fail
October 2024
Henry Ford Health, Detroit, MI.
Article Synopsis
- The study investigates the use of cangrelor in patients with myocardial infarction (MI) who also have cardiogenic shock (CS), focusing on the infusion duration and transition to oral medications.
- A total of 249 patients with CS were analyzed, with significant observations on demographics, infusion times, and the occurrence of major adverse cardiovascular events (MACEs) and bleeding risks.
- The findings showed that patients with CS had longer cangrelor infusions compared to others, and that the use of mechanical circulatory support (MCS) was linked to longer infusion times and an increased risk of bleeding.
Using a Military-Civilian Partnership to Enhance Clinical Readiness and Sustainment for Air Force Critical Care Nurses.
Crit Care Nurse
October 2024
Capt Roman Aguon Salas, USAF, NC, is pursuing a second master's degree at San Diego State University, California.
Background: Decreases in size, capability, clinical volumes, case mixes, and complex care opportunities in military treatment facilities contribute to the atrophy of clinical skills among medical professionals in these facilities.
Local Problem: The COVID-19 pandemic resulted in a 39% decline in admissions to a military critical care unit. The decrease in patient census contributed to skill sustainment challenges.
The cardioprotective effects of adenosine-induced cardioplegic arrest versus saline in aortic valve replacement patients: A randomized controlled trial.
Scand J Surg
December 2024
Heart Hospital, Tampere University Hospital, Tampere, Finland.
Article Synopsis
- The study aimed to assess the impact of an adenosine bolus compared to saline during the initial cardioplegia on patient outcomes in aortic valve replacement (AVR) surgeries.
- During the trial, 45 patients were randomized to receive either adenosine or saline, with various cardiac function metrics measured over time.
- The results indicated no significant differences in cardiac index or other secondary outcomes between the two groups, although the left ventricular stroke work index was lower in the adenosine group.
C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms.
Front Immunol
September 2023
Institute of Cardiovascular Science, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
Background: C-reactive protein (CRP) levels are elevated in patients with abdominal aortic aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA pathogenesis.
Methods: CRP deficient and wild type (WT) male mice were subjected to AAA induction via transient intra-aortic infusion of porcine pancreatic elastase.
Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms.
JVS Vasc Sci
March 2023
Department of Surgery, Stanford University School of Medicine, Stanford, CA.
Objective: Metformin treatment attenuates experimental abdominal aortic aneurysm (AAA) formation, as well as reduces clinical AAA diameter enlargement in patients with diabetes. The mechanisms of metformin-mediated aneurysm suppression, and its efficacy in suppressing established experimental aneurysms, remain uncertain.
Methods: Experimental AAAs were created in male C57BL/6J mice via intra-aortic infusion of porcine pancreatic elastase.
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