The growing importance of critical infrastructure systems (CIS) makes maintaining their normal operation against deliberate attacks such as terrorism a significant challenge. Combining game theory and complex network theory provides a framework for analyzing CIS robustness in adversarial scenarios. Most existing studies focus on single-layer networks, while CIS are better modeled as multilayer networks. Research on multilayer network games is limited, lacking methods for constructing incomplete information through link hiding and neglecting the impact of cascading failures. We propose a multilayer network Stackelberg game model with incomplete information considering cascading failures (MSGM-IICF). First, we describe the multilayer network model and define the multilayer node-weighted degree. Then, we present link hiding rules and a cascading failure model. Finally, we construct MSGM-IICF, providing methods for calculating payoff functions from the different perspectives of attackers and defenders. Experiments on synthetic and real-world networks demonstrate that link hiding improves network robustness without considering cascading failures. However, when cascading failures are considered, they become the primary factor determining network robustness. Dynamic capacity allocation enhances network robustness, while changes in dynamic costs make the network more vulnerable. The proposed method provides a new way of analyzing the robustness of diverse CIS, supporting resilient CIS design.
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http://dx.doi.org/10.3390/e26110976 | DOI Listing |
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Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Prostate cancer remains a significant global health concern, with over 1.4 million new cases diagnosed and more than 330,000 deaths each year. The primary clinical challenge that contributes to poor patient outcomes involves the failure to accurately predict and treat at the onset of metastasis, which remains an incurable stage of the disease.
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University of Central Florida, College of Medicine, Orlando, Florida, USA.
Unlabelled: Persistent viral infections can be an important medical problem, with persistently infected (PI) cells extending viral shedding, maintaining inflammation, and providing potential sources for new viral variants. Given that PI cells can acquire resistance to some innate immune pathways, we tested the hypothesis that complement (C')-mediated lysis of parainfluenza virus 5 (PIV5)-infected cells would differ between acute-infected and PI cells. Biochemical and real-time cell viability assays showed effective C'-mediated lysis of A549 lung cells acutely infected with PIV5, through pathways that depended on C3 and C5, but largely independent of C6.
View Article and Find Full Text PDFEur Heart J
January 2025
Department of Cardiology, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, Manuel de Falla, 1, 28222 Majadahonda, Madrid, Spain.
Development of specific therapies addressing the underlying diseases' mechanisms constitutes the basis of precision medicine. Transthyretin cardiac amyloidosis (ATTR-CM) is an exemplar of precise therapeutic approach in the field of heart failure and cardiomyopathies. A better understanding of the underlying pathophysiology, more precise data of its epidemiology, and advances in imaging techniques that allow non-invasive diagnosis have fostered the development of new and very effective specific therapies for ATTR-CM.
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The Second Hospital of Nanjing, Affiliated Hospital to Nanjing University of Chinese Medicine, Nanjing, China.
Human adenovirus is an infectious agent that causes respiratory infections in adults and children. It has been found that immunocompromised children are highly susceptible to this pathogen, as it can swiftly evolve into severe pneumonia with multiple sequelae. Due to the lack of immunity in children, the body's response mechanisms to innate and acquired immunity are specialized.
View Article and Find Full Text PDFPhysiol Rep
September 2024
Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.
Heart failure with preserved ejection fraction (HFpEF) has recently emerged as an insidiously and increasingly prevalent heart failure phenotype. HFpEF often occurs in the context of hypertension and obesity and presents with diastolic dysfunction, ventricular hypertrophy, and myocardial fibrosis. Despite growing study of HFpEF, the causal links between early metabolic changes, bioenergetic perturbations, and cardiac structural remodeling remain unclear.
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