We propose two families of asymptotically local minimax lower bounds on parameter estimation performance. The first family of bounds applies to any convex, symmetric loss function that depends solely on the difference between the estimate and the true underlying parameter value (i.e., the estimation error), whereas the second is more specifically oriented to the moments of the estimation error. The proposed bounds are relatively easy to calculate numerically (in the sense that their optimization is over relatively few auxiliary parameters), yet they turn out to be tighter (sometimes significantly so) than previously reported bounds that are associated with similar calculation efforts, across many application examples. In addition to their relative simplicity, they also have the following advantages: (i) Essentially no regularity conditions are required regarding the parametric family of distributions. (ii) The bounds are local (in a sense to be specified). (iii) The bounds provide the correct order of decay as functions of the number of observations, at least in all the examples examined. (iv) At least the first family of bounds extends straightforwardly to vector parameters.
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http://dx.doi.org/10.3390/e26110944 | DOI Listing |
Trop Anim Health Prod
January 2025
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 38541, Republic of Korea.
To improve the quality and yield of the Korean beef industry, selection criteria often focus on estimated breeding values for carcass weight (CWT), eye muscle area (EMA), backfat thickness (BF), and marbling score (MS). This study estimated genetic parameters and assessed the accuracy of genomic estimated breeding values (GEBVs) using SNP weighting methods. We compared the accuracy of these methods with the genomic best linear unbiased prediction (GBLUP) and various Bayesian approaches (BayesA, BayesB, BayesC, and BayesCPi) for the specified traits.
View Article and Find Full Text PDFArch Gynecol Obstet
January 2025
Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey.
Introduction: Pregnancy induces a hypercoagulable state, characterized by increased coagulation factors and decreased anticoagulants, alongside ongoing fibrinolysis marked by elevated D-dimer (DD) levels. Reference values for DD in pregnancy often exceed the non-pregnant cutoff due to these changes. Elevated DD levels are common in late pregnancy and may correlate with complications such as gestational diabetes, hypertension, and preterm delivery, particularly in cases of preterm premature rupture of membranes (PPROM).
View Article and Find Full Text PDFJ Biomech Eng
January 2025
State Key Laboratory of Fluid Power and Mechatronic Systems, Department of Mechanical Engineering, Zhejiang University, Hangzhou, 315000, China.
Due to individual differences, accurate identification of tissue elastic parameters is essential for biomechanical modeling in surgical guidance for hepatic venous injections. This paper aims to acquire the absolute Young's modulus of heterogeneous soft tissues during endoscopic surgery with 2D ultrasound images. First, we introduced a force-sensor-less approach that utilizes a pre-calibrated soft patch with a known Young's modulus and its ultrasound images to calculate the external forces exerted by the probe on the tissue.
View Article and Find Full Text PDFAnn Med
December 2025
Central Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: Despite surgical and intravesical chemotherapy interventions, non-muscle invasive bladder cancer (NMIBC) poses a high risk of recurrence, which significantly impacts patient survival. Traditional clinical characteristics alone are inadequate for accurately assessing the risk of NMIBC recurrence, necessitating the development of novel predictive tools.
Methods: We analyzed microarray data of NMIBC samples obtained from the ArrayExpress and GEO databases.
J Appl Physiol (1985)
January 2025
Medical Physics Graduate Program, Duke University, Durham, North Carolina, United States.
Hyperpolarized Xe MRI/MRS enables quantitative mapping of function in lung airspaces, membrane tissue, and red blood cells (RBCs) within the pulmonary capillaries. The RBC signal also exhibits cardiogenic oscillations that are reduced in pre-capillary pulmonary hypertension (PH). This effect is obscured in patients with concomitant defects in transfer from airspaces to RBCs, which increase RBC oscillation amplitudes.
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