Introduction: Chronic functional constipation (CFC) is one of the most challenging types of constipation which negatively influences patients' quality of life. Recently, investigators mentioned pelvic floor muscles (PFMs) as an influential factor in the symptoms of patients with CFC, while its underlying mechanism is still unclear. The aim of this study is to investigate the PFMs function in people with and without CFC using transabdominal ultrasound.
Method: In this cross-sectional and prospective study, we utilized a convenience sample of 200 individuals (100 CFC and 100 non-CFC) aged between 20 and 50 years old. The data collection included the measurement of the bladder base diameters displacement between rest and contraction using transabdominal ultrasound in all subjects. Also, individuals' diet and physical activity were assessed as contributing factors using International Physical Activity Questionnaire and Food Frequency Questionnaire.
Results: The result of MANCOVA revealed no significant group by physical activity level interaction for bladder base diameter at rest and bladder base displacement. Moreover, the Kruskal-Wallis test showed significant difference in physical activity level of patients with CFC in comparison with healthy individuals. Independent T-test results revealed that there is a significant difference in the consumption of fat and dairy subgroups between two groups.
Discussion And Conclusions: The results indicated that there is no significant association between the bladder base displacement and the development of CFC. Moreover, our data revealed that people with CFC experience a more sedentary life and consume more fat and dairy products in comparison with individuals without CFC.
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http://dx.doi.org/10.1016/j.jbmt.2024.04.052 | DOI Listing |
Characterization of tumor epigenetic aberrations is integral to understanding the mechanisms of tumorigenesis and provide diagnostic, prognostic, and predictive information of high clinical relevance. Among the different tumor-associated epigenetic signatures, 5 methyl-cytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the two most well-characterized DNA methylation alterations linked to cancer pathogenesis. 5hmC has a tissue-specific distribution and its abundance is subjected to changes in tumor DNA, making it a promising biomarker.
View Article and Find Full Text PDFDigit Health
January 2025
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.
Objective: Accurate measurement of pelvic floor muscle (PFM) strength is crucial for the management of pelvic floor disorders. However, the current methods are invasive, uncomfortable, and lack standardization. This study aimed to introduce a novel noninvasive approach for precise PFM strength quantification by leveraging extracorporeal surface perineal pressure (ESPP) measurements and machine learning algorithms.
View Article and Find Full Text PDFMol Cells
January 2025
College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea; Gradutate Program in Innovative Biomaterials Convergence, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address:
The base excision repair (BER) pathway is a critical mechanism in genomic stability. This review investigates the role of the BER pathway in advanced cancer therapies considering the pivotal role of genetic factors in cancer patient responses and prognosis. BER factors significantly influence genetic instability and cancer prognosis, as well as the effectiveness of chemotherapy and radiation therapy.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Caring Sciences, School Health and Welfare, Dalarna University, Falun, Sweden.
There is currently a lack of clarity concerning the types and frequency of mucosa injuries occurring in urine bladders among patients with indwelling urine catheters that are of modern design and material. The aim of the study was to identify and present the available information regarding mucosa injuries in urine bladders among adult patients with indwelling urine catheters. The research question was: What is known about mucosa injuries in urine bladders among patients with indwelling urine catheters? A scoping review applying the patient, exposure, and outcome framework.
View Article and Find Full Text PDFNeurourol Urodyn
January 2025
Department of Medicine, College of Health Sciences, Faculty of Medicine & Dentistry, Division of Geriatric Medicine, Edmonton, Alberta, Canada.
Context: Improved continence outcomes are reliant on identification of unmet need, education delivery, and shared decision-making. The evidence base on which to derive innovative approaches in these areas was unclear.
Methods: A debate held at the International Consultation on Incontinence-Research Society meeting, held in Bristol in June 2024, considered ways to improve research requirements to advance these areas.
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