Background: Individuals with chronic ankle instability (CAI) have problems in function. The purpose of this study was to systematically investigate the short- or long-term effects of various orthoses on function of these people.
Methods: Randomized controlled trial (RCT) studies reporting on the short- or long-term effects of orthotic intervention on functional performance in individuals with CAI were identified through PubMed, Cochrane Library, PEDro, MEDLINE via Ovid, and Scopus databases from inception to July 2022. Two reviewers independently extracted data and assessed the risk of bias and quality of the studies using ROB tool and PEDro scale, respectively.
Results: Eleven RCTs published from 2012 to 2022 were included in this review. The studies were of a fair or good quality. The risk of bias was low in 50 percent and high in 16.7 percent of the studies. The mSEBT in the posterolateral and posteromedial directions were improved both in the short- and long-term application of orthoses. Single leg hop did not change but single leg stance was improved more in the experimental group who used orthoses for 4 weeks.
Conclusion: Various tapes can improve dynamic balance immediately after application and their effects would last up to 2 months. Therefore, they can be used during training. Athletes with CAI who want to perform better should use the tape at least two weeks before competing to take advantage of its long-term effects. The timing of application of orthotic appliances, needs to be adjusted according to the relevant function.
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http://dx.doi.org/10.1016/j.jbmt.2023.01.004 | DOI Listing |
Alzheimers Dement
December 2024
Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background: Acetylcholine, a neurotransmitter critical for cognitive functions, including attention, memory, and sociability, is essential for maintaining synaptic integrity. Deficits in acetylcholine levels are linked to cognitive impairments. Heterozygous VAChT KD (VAChT KDHET) mice, characterized by reduced vesicular acetylcholine transporter protein production, exhibit cognitive impairments due to diminished acetylcholine release.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Background: The effectiveness of multimodal lifestyle interventions to prevent dementia is being validated. Since a relatively long period (∼2 years) is required for manifesting an impact on cognitive function, the exploration of an alternative marker that exhibits changes within a comparatively brief duration, thereby prognosticating future alterations in cognitive function, is needed. The decline in gait function is associated with cognitive impairment and is also a predictor of future cognitive decline.
View Article and Find Full Text PDFBackground: Focused Ultrasound-induced Blood-Brain Barrier Opening (FUS-BBBO) has demonstrated preventative and therapeutic efficacy for improving cognitive and pathological decline in Alzheimer's Disease (AD). Previous work has demonstrated highly specific binding of a novel Re complex (Re-1) complex to amyloid-β (Aβ) in vitro, subsequently inhibiting fibril formation and reducing Aβ-induced cytotoxicity in neuronal cell cultures. The aim of this preliminary study is to evaluate the efficacy of early intervention combining FUS-BBBO and Re-1 for anxiety amelioration and memory improvement in a triple transgenic (3xTg)-AD mouse model.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
German Center for Neurodegenerative Diseases e.V. (DZNE), Site Rostock/Greifswald, Greifswald, Germany.
Background: Previous trials reported that collaborative Dementia Care Management (cDCM) could be effective for patients and caregivers and cost-effective for healthcare systems in the short term. However, long-term evidence is lacking. Therefore, the study's objective was to determine the long-term efficacy and cost-effectiveness of cDCM compared with usual care.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Northwest Research Group on Aging, Seattle, WA, USA.
Background: Sexual and gender minority (SGM) older adults experience disparities in subjective cognitive impairment when compared to heterosexuals of similar age. Yet, SGM older adults and their care partners living with dementia/memory loss face substantial barriers to accessing culturally relevant health and dementia care. To address the gap in culturally relevant interventions, we tested the efficacy of a first of its kind stigma reduction, cognitive behavioral intervention for SGM older adults living with dementia/memory loss and their care partners, Aging with Pride: Innovations in Empowerment and Action (IDEA).
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