Dose-dependent effects of anthocyanin-rich extracts on obesity-induced inflammation and gut microbiota modulation.

Biofactors

Laboratório de Nutrição e Fisiologia Endócrina (LaNFE), Departamento de Biociências, Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, São Paulo, Brazil.

Published: December 2024

AI Article Synopsis

  • Obesity and its related inflammation are major health issues, and anthocyanins—compounds found in fruits and veggies—show promise in helping to combat these problems.
  • The review examines how the effects of anthocyanins on obesity can vary with different dosages, looking at their absorption, structure, and how they interact with the gut microbiota and immune responses.
  • It emphasizes the need for more research to determine the optimal dosages for anthocyanins to maximize health benefits, considering individual differences and potential clinical applications for obesity management.

Article Abstract

Obesity and its associated inflammatory state pose a significant health burden. Anthocyanins, bioactive compounds found in fruits and vegetables, have garnered interest in their potential to attenuate these conditions. Understanding the dose-dependent response of anthocyanins is essential for optimizing their therapeutic potential in preventing and managing obesity. This comprehensive review explores the current knowledge on the dose-dependent effects of anthocyanins on obesity in both human and animal models, analyzing the structure and mechanism of absorption of these compounds. The article also highlights the diverse mechanisms underlying anthocyanin action, the symbiosis between anthocyanins and gut microbiota impacting metabolite production, influencing diverse health outcomes, modulating cytokines, and activating anti-inflammatory pathways. Additionally, their impact on energy metabolism and lipid regulation is discussed, highlighting potential contributions to weight management through AMPK and PPARγ pathways. Despite promising results, dose-dependent effects are fundamental considerations, with some studies indicating less favorable outcomes at higher doses. Future research should focus on optimizing dosages, accounting for individual responses, and translating findings into effective clinical applications for obesity management.

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Source
http://dx.doi.org/10.1002/biof.2144DOI Listing

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