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Recent Advances in Tetra-Coordinate Boron-Based Photoactive Molecules for Luminescent Sensing, Imaging, and Anticounterfeiting.
Precis Chem
January 2025
Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, P. R. China.
Tetra-coordinate boron-based fluorescent materials hold considerable promise across chemistry, biology and materials science due to their unique and precisely tunable optoelectronic properties. The incorporation of the heteroatom boron (B) enables these materials to exhibit high luminescence quantum yields, adjustable absorption and emission wavelengths, and exceptional photostability. This review examines the molecular design and applications of tetra-coordinate boron-based photoactive molecules, highlighting their roles in fluorescence sensing, anticounterfeiting, and imaging.
View Article and Find Full Text PDFResponse to the SAMHSA Clinical Advisory: Considerations for Genetic Testing in the Assessment of Substance Use Disorder Risk.
Subst Abuse Rehabil
January 2025
Department of Psychiatry, Texas Tech University Health Sciences, School of Medicine, Midland, TX, USA.
Metabolomics integrated genomics approach: Understanding multidrug resistance phenotype in MCF-7 breast cancer cells exposed to doxorubicin and ABCA1/EGFR/PI3k/PTEN crosstalk.
Toxicol Rep
June 2025
National Research Center, Therapeutic Chemistry Department, Al Bohouth Street, Egypt.
Resistance of cancer cells, especially breast cancer, to therapeutic medicines represents a major clinical obstacle that impedes the stages of treatment. Carcinoma cells that acquire resistance to therapeutic drugs can reprogram their own metabolic processes as a way to overcome the effectiveness of treatment and continue their reproduction processes. Despite the recent developments in medical research in the field of drug resistance, which showed some explanations for this phenomenon, the real explanation, along with the ability to precisely predict the possibility of its occurrence in breast cancer cells, still necessitates a deep consideration of the dynamics of the tumor's response to treatment.
View Article and Find Full Text PDFDeveloping human upper, lower, and deep lung airway models: Combining different scaffolds and developing complex co-cultures.
J Tissue Eng
January 2025
Core Facility Tissue Engineering, Institute of Chemistry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Advanced in vitro models are crucial for studying human airway biology. Our objective was the development and optimization of 3D in vitro models representing diverse airway regions, including deep lung alveolar region. This initiative was aimed at assessing the influence of selective scaffold materials on distinct airway co-culture models.
View Article and Find Full Text PDFImpact of using time-averaged exposure metrics on binary endpoints in exposure-response analyses.
Front Pharmacol
January 2025
Certara Inc., Melbourne, VIC, Australia.
Exposure-response (ER) analyses are routinely performed as part of model-informed drug development to evaluate the risk-to-benefit ratio for dose selection, justification, and confirmation. For logistic regression analyses with binary endpoints, several exposure metrics are investigated, based on pharmacological plausibility, including time-averaged concentration to event (C). C is informative because it accounts for dose interruptions, modifications, and reductions and is therefore often compared against ER relationships identified using steady-state exposures.
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