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Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis.
Nat Rev Immunol
January 2025
Preprint Club, University of Toronto, Toronto, Ontario, Canada.
Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection.
Immun Ageing
November 2024
Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.
Ageing is a major risk factor that contributes to increased mortality and morbidity rates during influenza A virus (IAV) infections. Macrophages are crucial players in the defense against viral infections and display impaired function during ageing. However, the impact of ageing on macrophage function in response to an IAV infection remains unclear and offers potential insight for underlying mechanisms.
View Article and Find Full Text PDFSpinster homolog 2/S1P signaling ameliorates macrophage inflammatory response to bacterial infections by balancing PGE production.
Cell Commun Signal
September 2024
Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China.
Article Synopsis
- - Mitochondria are essential for how macrophages (a type of immune cell) respond to bacterial infections, and the protein Spns2, which regulates S1P secretion, influences mitochondrial functions in these cells.
- - Researchers isolated peritoneal macrophages from both normal and Spns2-deficient rats to explore how Spns2/S1P signaling affects mitochondrial functions and inflammation, using techniques like metabolomics, RNA sequencing, and various assays.
- - The study identifies prostaglandin E (PGE) as a key factor in the communication between Spns2/S1P signaling and mitochondria; a lack of Spns2 leads to high PGE levels that disrupt mitochondrial respiration and cause inflammation-related
Analysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics.
Biomedicines
August 2024
Department of Microbiology and Medical Zoology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.
Article Synopsis
- HIV-1 infects macrophages that release neurotoxic substances like cathepsin B (CATB), leading to cognitive issues, with cocaine enhancing this effect.
- Treatment with BD1047, a sigma-1 receptor antagonist, prior to cocaine exposure lowers HIV-1 replication and CATB secretion, reducing neuronal cell death.
- Proteomic analysis revealed that BD1047 dysregulated 80 proteins related to HIV-1, CATB, and mitochondrial functions, suggesting it helps protect cells by improving mitochondrial health and reducing neurotoxicity.
TLR7-Induced Mitochondrial Reactive Oxygen Species Production in Monocyte-derived Dendritic Cells Drives IL-12-Dependent NK Cell Activation and Enhances Antitumor Immunity.
J Immunol
October 2024
Cellular Immunology Laboratory, Department of Zoology, University of Burdwan, Bardhaman, India.
Dendritic cell (DC)-based vaccines are promising immunotherapies for cancer. Although DC-based therapies are known to activate tumor-specific T cells, the interplay between DCs and NK cells in this setting is not fully understood. In this study, we demonstrated a novel TLR7/ mitochondrial reactive oxygen species (mROS)/IL-12 axis that drives potent NK cell responses against tumors.
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