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Light-Activatable Ubiquitin for Studying Linkage-Specific Ubiquitin Chain Formation Kinetics.
Adv Sci (Weinh)
December 2024
Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn Str. 4a, 44227, Dortmund, Germany.
Ubiquitination is a dynamic post-translational modification governing protein abundance, function, and localization in eukaryotes. The Ubiquitin protein is conjugated to lysine residues of target proteins, but can also repeatedly be ubiquitinated itself, giving rise to a complex code of ubiquitin chains with different linkage types. To enable studying the cellular dynamics of linkage-specific ubiquitination, light-activatable polyubiquitin chain formation is reported here.
View Article and Find Full Text PDFVisual quality of life in NMOSD and MOGAD: profiles, dynamics and associations with ageing and vision.
J Neurol
December 2024
APHM, Hôpital de la Timone, CEMEREM, Marseille, France.
Objective: In this multicentric study, we were interested in the vision-related quality of life and its association with visual impairment in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in comparison to multiple sclerosis (MS) and healthy controls.
Methods: We analysed extracted data from the German NEMOS registry including National Eye Institute Visual Function Questionnaire (NEI-VFQ) scores, high and low contrast visual acuity (HCVA, LCVA), visually evoked potentials (VEP) and the scores for the expanded disability status scale (EDSS) and other neurological tests which assessed their disease-related impairment. The mean follow-up time of our patients was 1.
"A key experience in my education was the double-degree exchange program that I did during my BSc. Experiencing different perspectives of education and culture in Brazil and France expanded my horizons permanently… Guaranteed to make me laugh is a good surrealist movie…" Find out more about Lucas Foppa in his Introducing… Profile.
View Article and Find Full Text PDFUnveiling the power of high-dimensional cytometry data with cyCONDOR.
Nat Commun
December 2024
Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
High-dimensional cytometry (HDC) is a powerful technology for studying single-cell phenotypes in complex biological systems. Although technological developments and affordability have made HDC broadly available in recent years, technological advances were not coupled with an adequate development of analytical methods that can take full advantage of the complex data generated. While several analytical platforms and bioinformatics tools have become available for the analysis of HDC data, these are either web-hosted with limited scalability or designed for expert computational biologists, making their use unapproachable for wet lab scientists.
View Article and Find Full Text PDFResponse Letter to the Article: "Expanding horizons of indocyanine green in breast surgery".
Cir Esp (Engl Ed)
December 2024
Servicio de Cirugía General y Digestiva, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla; Servicio de Cirugía General y Digestiva, Hospital Quironsalud Sagrado Corazón, Sevilla.
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