AI Article Synopsis
- A 75-year-old woman was referred to the hospital due to dizziness, with CT scans revealing generalized lymphadenopathy and a 10 cm tumor in her left kidney, leading to a diagnosis of Hodgkin's lymphoma and left renal cell carcinoma.
- After starting chemotherapy for the lymphoma, metastases from the renal cancer appeared after a year, prompting a shift to combination therapy with Pembrolizumab and Axitinib.
- After experiencing gastritis and severe thrombocytopenia as side effects, treatment was adjusted, and she is currently on Cabozantinib with no recurrence of previous complications.
Article Abstract
A 75-year-old female who was referred to our hospital with dizziness as the main complaint. Computed tomographic (CT) and positron emission tomography-CT scans indicated the presence of generalized lymphadenopathy and a 10 cm tumor in her left kidney. Further evaluation led to a diagnosis of Hodgkin’s lymphoma and left renal cell carcinoma. Due to her poor general condition secondary to the lymphoma, she was referred to our institution where chemotherapy was promptly initiated. After one year, metastases to the sternum and right hilar lymph nodes from the renal cancer were detected. Therefore, treatment for the lymphoma was discontinued, and combination therapy with Pembrolizumab and Axitinib for the renal carcinoma was started. Eight months after starting treatment for kidney cancer, the patient developed gastritis as an immune-related adverse event (irAE), which improved with high-dose steroid therapy. Subsequently, severe thrombocytopenia developed following the initiation of steroid therapy but improved upon discontinuation of Axitinib. Currently, treatment is ongoing with Cabozantinib without recurrence of either gastritis or thrombocytopenia.
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| http://dx.doi.org/10.14989/ActaUrolJap_70_7_213 | DOI Listing |
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