AI Article Synopsis
- Parasites use various techniques to evade the host’s immune system, which can be beneficial in treating autoimmune and allergic diseases through a method known as "helminth therapy."
- Despite experimental evidence supporting the potential of parasites in combating autoimmune issues, like rheumatoid arthritis (RA), the exact mechanisms are not fully understood due to the variety of parasites and autoimmune disorders.
- This paper reviews how parasites can modulate the immune response, specifically their anti-arthritic effects, and explores the potential of using parasite-derived treatments as new options for managing RA.
Article Abstract
Parasites generally survive in their hosts by employing various immunomodulation and immune evasion mechanisms. "helminth therapy" is one strategy that harnesses these parasite-specific beneficial properties for the therapeutic treatment of autoimmune and allergic diseases. Although numerous experimental reports have documented the anti-autoimmune activities of parasitic infections and parasite-derived products, the underlying mechanisms remain insufficiently elucidated due to the significant diversity among parasite species and autoimmune conditions. Rheumatoid arthritis (RA) is one of the most prevalent autoimmune disorders, presenting a substantial opportunity for the therapeutic use of parasites as novel disease-modifying antirheumatic drugs (DMARDs). In this paper, we summarize the immunomodulatory properties of parasites, focusing on their anti-arthritic mechanisms, and discuss the potential of parasite-derived products for the treatment of RA.
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| http://dx.doi.org/10.1016/j.parint.2024.103000 | DOI Listing |
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