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Measuring the effects of ketogenic diet on neuropsychiatric disorder: A scoping review. | LitMetric

Measuring the effects of ketogenic diet on neuropsychiatric disorder: A scoping review.

Prog Neuropsychopharmacol Biol Psychiatry

Psychiatry Department, Texas Tech University Health Sciences Center, 3601 4th Street STOP 8103, Lubbock, TX 79430-8103, USA. Electronic address:

Published: November 2024

AI Article Synopsis

  • The scoping review investigates the ketogenic diet's potential effectiveness as a treatment for various neuropsychiatric disorders, noting that while there is interest, the overall effectiveness is still uncertain.
  • It considers a range of study types, including randomized controlled trials and observational studies, that follow DSM-5 guidelines for neuropsychiatric conditions.
  • The review analyzes 30 studies that suggest the ketogenic diet could improve symptoms in disorders like Autism, ADHD, depression, and anxiety, but highlights the need for more thorough research to validate its use as a standard treatment.

Article Abstract

Objective: This scoping review aims to examine the available literature on the ketogenic diet's (KD) efficiency as a potential therapeutic intervention for various neuropsychiatric disorders.

Introduction: The KD is a high-fat, low-carbohydrate diet that has been studied for its potential benefits in managing neuropsychiatric disorders. However, the extent of its effectiveness across a spectrum of these conditions remains unclear.

Inclusion Criteria: The study designs considered eligible encompassed randomized and non-randomized controlled trials, retrospective and prospective observational studies, and comparative effectiveness assessments. The criteria for including each study were specifically related to neuropsychiatric disorders, referring to the DSM-5 coding guidelines.

Methods: A systemic search was performed by an experienced reference librarian across multiple databases to pinpoint studies relevant to the influence of the ketogenic diet on neuropsychiatric disorders. All relevant articles were included that ranged over the last thirteen years. All relevant records identified were compiled into the Covidence systematic review software.

Results: A total of 30 studies were reviewed, which reported effects of the KD on neuropsychiatric disorders, including improvements in Global Developmental Delay, Childhood Autism, Attention Deficit/Hyperactivity Disorder (ADHD) symptoms, psychotic symptoms, Bipolar and Related Disorders, Depressive Disorder symptoms, anxiety symptoms, eating disorders, Substance-Related and Addictive Disorders, Major and Mild Neurocognitive Disorders, and Seizure Disorders.

Conclusion: The KD may serve as a promising therapeutic intervention for various neuropsychiatric disorders. However, the evidence is heterogeneous, and further rigorous research is needed to establish the KD as a standard treatment for these disorders and to understand the underlying mechanisms of its effects.

Implications For Practice: This review underscores the need for healthcare professionals to consider the potential benefits and limitations of the KD when managing patients with neuropsychiatric disorders. It also highlights the importance of individualized treatment plans based on the specific needs and responses of each patient.

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Source
http://dx.doi.org/10.1016/j.pnpbp.2024.111205DOI Listing

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