AI Article Synopsis
- * Significant down-regulation of specific genes related to inflammation and cell signaling was observed, along with a notable reduction in the activity of matrix metalloproteinase 9 (MMP-9).
- * Despite these changes, other inflammatory and antioxidant factors showed no significant differences, suggesting that grape pomace may improve animal welfare while also promoting the use of a valuable agricultural by-product.
Article Abstract
The present study aims to evaluate the effect of a dietary supplementation with 10% grape pomace (GP) on the whole blood transcriptome of lactating ewes. By applying a logFC higher than 0.5 or lower than -0.5 and a false discovery rate (FDR) <0.05, the down-regulation of genes coding for plexin C1, ethanolamine kinase 1, tax1-binding protein 1, transmembrane 9 superfamily member 2, and Beclin-1 was observed in animals that received the dietary supplementation. This aspect was also accompanied by a reduction in the blood activity of matrix metalloproteinase 9 (MMP-9; < 0.05), a gelatinase commonly involved in both acute and chronic pathological events. The ELISA test on other factors involved in inflammatory processes, interleukin 1 (IL-1) and tumor necrosis factor α (TNF-α), as well as in the antioxidant response, glutathione peroxidase (GPx), and catalase (CAT), did not reveal any significant changes ( > 0.05). Overall, the introduction of GP in the diet of ewes gave indications of greater efficacy in preserving animal welfare, with interesting cues regarding the valorization of a by-product with a high biological value.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599069 | PMC |
| http://dx.doi.org/10.3390/vetsci11110536 | DOI Listing |
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