Four new polyketides, heterocornol Y (), stemphyindan (), pestalospirane C (), and stemphyspyrane (), along with five known ones (-) were isolated from the endophytic fungus 17035 (SG17035) based on the One Strain Many Compounds (OSMAC) strategy allied with an LC-MS approach. These structures were elucidated through extensive spectroscopic analyses, single-crystal X-ray diffraction, and C NMR-DP4 analysis. Pestalospirane C () and stemphyspyrane () featured unprecedented spiroketal skeletons. In addition, the putative biosynthetic logic for compounds - was proposed. Antibacterial and cytotoxic activities of compounds - were evaluated. Stemphyspyrane () displayed promising antibacterial activity against different pathogens, especially against , and methicillin-resistant (MRSA) with MIC values of 3.125 μM, 6.25 μM, and 12.5 μM, respectively. It is promising as an antibacterial agent for further optimization.
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| http://dx.doi.org/10.3390/jof10110737 | DOI Listing |
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