Although the complication rate of percutaneous coronary intervention is low, coronary artery perforation occurs in 0.2-0.5% of cases. Intracoronary glue injection is not an established treatment option, with only a few cases reported in the literature and no reported use of n-hexyl-cyanoacrylate. Case report: A 75-year-old man was diagnosed with a non-ST elevation myocardial infarction. Since there was no acute chest pain and no signs of ongoing ischemia on the ECG, diagnostic coronary angiography was performed the day after arrival. The coronary angiography revealed a proximal subocclusion of the left anterior descending artery. The lesion was successfully predilated, and a drug-eluting 5 × 28 mm stent was implanted, occluding two small diagonal branches. While attempting to create a gap in the stent to revascularize the occluded branch, a side branch perforation was detected. This was successfully treated by occluding the branch with an intracoronary cyanoacrylate glue injection. No signs of cardiac tamponade were observed during follow-up after the procedure, and the patient was soon discharged to rehabilitation. Conclusions: Coronary artery perforation is a serious complication of percutaneous coronary intervention. Intracoronary glue injection and embolization of the perforated side branch appear to be a safe and effective technique for managing this complication.
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http://dx.doi.org/10.3390/jcdd11110347 | DOI Listing |
Endosc Ultrasound
December 2024
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
Cells
January 2025
Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-8530, Japan.
Boron (B) neutron capture therapy (BNCT) is a novel non-invasive targeted cancer therapy based on the nuclear capture reaction B (n, alpha) Li that enables the death of cancer cells without damaging neighboring normal cells. However, the development of clinically approved boron drugs remains challenging. We have previously reported on self-forming nanoparticles for drug delivery consisting of a biodegradable polymer, namely, "AB-type" Lactosome nanoparticles (AB-Lac particles)- highly loaded with hydrophobic B compounds, namely -Carborane (Carb) or 1,2-dihexyl--Carborane (diC6-Carb), and the latter (diC6-Carb) especially showed the "molecular glue" effect.
View Article and Find Full Text PDFBackground: Lymphatic leaks are associated with significant mortality and morbidity. Intranodal lymphangiography (ILAG) involves the direct injection of ethiodised lipid into the hilum of lymph nodes. It is diagnostic procedure that can have therapeutic effects secondary to a local sclerosant effect.
View Article and Find Full Text PDFJ Nippon Med Sch
January 2025
Department of Radiology, Nippon Medical School.
As a blood flow control technique for embolization using glue (n-butyl cyanoacrylate; NBCA) for peripheral artery aneurysm/pseudoaneurysm, we placed a vascular plug or coils at the proximal inflow vessel before glue injection. We describe this maneuver, which we call the glue in lockdown technique. Four peripheral aneurysms-two pulmonary artery pseudoaneurysms, one pancreaticoduodenal arcade pseudoaneurysm, and one internal iliac artery aneurysm-deemed unsuitable for conventional embolization because of abnormal blood flow, coagulopathy, or anatomical complexity were embolized with our technique.
View Article and Find Full Text PDFActa Gastroenterol Belg
January 2025
Department of gastroenterology, Ghent University Hospital, Ghent, Belgium.
Acute gastric variceal bleeding is a rare but serious complication of portal hypertension. Initial therapy for bleeding gastric varices focuses on acute hemostasis. In this regard, endoscopic cyanoacrylate injection (ECI) is the first-line approach.
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