AI Article Synopsis
- Long-term survivors of pancreatic cancer after surgery are rare, and a recent Italian survey aims to understand factors affecting their survival outcomes.
- The survey, endorsed by key oncological associations, gathered responses from surgeons to analyze demographics, clinical practices, and survival rates, revealing that long-term survival (LTS) is defined as being alive at 5 years post-surgery.
- Findings indicated improved survival rates for patients post-2013, especially in high-volume centers with multidisciplinary approaches, as well as those receiving neoadjuvant chemotherapy and having low-grade tumors.
Article Abstract
Long-term survivors after pancreatic resection for PDAC are rare, constituting a specific subset of patients that remains poorly understood. The aim of this survey is to describe the current landscape related to survival in the Italian context and identify factors associated with long-term survival. An online survey, conducted by the Italian Society of Oncological Surgery (SICO) and endorsed by Italian Association of the Study of the Pancreas (AISP) and Italian Association of Hepatobiliary Pancreatic Surgery (AICEP), was distributed to surgeons in July 2023. The survey included 27 multiple-choice questions covering demographics, professional details, clinical practices, and long-term survival data. Responses were analyzed using descriptive statistics and multinomial logistic regression to identify factors related to long-term survival. The majority of surgeons (46.9%) considered LTS as "alive at 5 years, regardless of disease-free status". The percentage of patients alive at 5 years post-2013 was higher compared to pre-2013. Almost all centers (93.2%) held multidisciplinary discussions. Very high-volume centers (> 100 resections/year) in comparison to very low-volume (< 10 resections/year) showed better long-term survival rates. No difference in survival were observed between centers with low, medium, high, and very high volumes. In addition, centers with multidisciplinary approach showed better survival rates. Centers with more neoadjuvant chemotherapy rates, low-grade and low-stage tumors were also associated with improved survival outcomes. This survey has allowed to understand the Italian scenario regarding survival in patients undergoing surgery for PDAC.
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| http://dx.doi.org/10.1007/s13304-024-02039-3 | DOI Listing |
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