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Risk of estrogen-driven malignancies in females on 5-alpha reductase inhibitors.
Arch Dermatol Res
November 2024
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, 833 Chestnut Street, Philadelphia, PA, 19107, USA.
Thrombotic complications in pregnancy: a case-based review of the evidence.
J Thromb Haemost
October 2024
Division of Hematology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Pregnancy is a prothrombotic state due to an estrogen-driven shift in the coagulation system, increased venous stasis, and external restriction of blood flow caused by the gravid uterus. Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in pregnancy. Preventing, recognizing, and treating thrombosis in pregnancy, as well as the postpartum period, often challenges decision making in the clinical setting.
View Article and Find Full Text PDFEstrogen receptor 1 chromatin profiling in human breast tumors reveals high inter-patient heterogeneity with enrichment of risk SNPs and enhancer activity at most-conserved regions.
Genome Res
May 2024
Division of Oncogenomics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands;
Estrogen Receptor 1 (ESR1; also known as ERα, encoded by gene) is the main driver and prime drug target in luminal breast cancer. ESR1 chromatin binding is extensively studied in cell lines and a limited number of human tumors, using consensi of peaks shared among samples. However, little is known about inter-tumor heterogeneity of ESR1 chromatin action, along with its biological implications.
View Article and Find Full Text PDFEstrogen Receptor alpha (ERα) is the main driver and prime drug target in luminal breast. ERα chromatin binding is extensively studied in cell lines and a limited number of human tumors, using consensi of peaks shared among samples. However, little is known about inter-tumor heterogeneity of ERα chromatin action, along with its biological implications.
View Article and Find Full Text PDFEstrogens and the risk of breast cancer: A narrative review of literature.
Heliyon
September 2023
Faculty of Medicine, Yarmouk University, P.O Box 566, 21163, Irbid, Jordan.
In female mammals, the development and regulation of the reproductive system and non-reproductive system are significantly influenced by estrogens (oestrogens). In addition, lipid metabolism is another physiological role of estrogens. Estrogens act through different types of receptors to introduce signals to the target cell by affecting many estrogen response elements.
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