AI Article Synopsis
- Immune checkpoint inhibitors (ICIs) have changed the game in cancer treatment but often show low response rates, prompting the exploration of dual blockade strategies for better results.
- Researchers developed hybrid cell membrane nanovesicles that combine PD-1 and SIRPα receptors to improve treatment efficacy for melanoma by enhancing immune response.
- In tests on a melanoma mouse model, these nanovesicles led to a significant 77% reduction in tumor growth and triggered a strong immune response, showcasing their potential as effective new tools for cancer therapy.
Article Abstract
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, demonstrating unprecedented efficacy against advanced cancers. However, their clinical applications are significantly hampered by low overall response rates. Dual blockade of two immune checkpoints represents a promising strategy to enhance immunotherapeutic efficacy. In this study, we developed hybrid cell membrane nanovesicles adorned with PD-1 and SIRPα receptors for combination immunotherapy in melanoma. Our hybrid nanovesicles (PD-1/SIRPα NVs) demonstrated high specificity to PD-L1 and CD47 ligands, facilitating the phagocytosis of melanoma cells by macrophages. In a melanoma mouse model, PD-1/SIRPα NVs significantly suppressed 77% of tumor growth and elicited a robust antitumor immune response for immunotherapy. In conclusion, our findings highlight the promising potential of PD-1/SIRPα NVs as novel and effective ICIs for cancer immunotherapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586202 | PMC |
| http://dx.doi.org/10.3389/fphar.2024.1487940 | DOI Listing |
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