Background: Extended-spectrum β-lactamase and carbapenemase-producing are an increasing problem for patients today. Data on clinical samples for ESBL and carbapenemase-producing for surgical site infection patients in developing countries are limited, including Ethiopia, mainly due to resource constraints. Hence, this study aimed to determine the prevalence of extended-spectrum beta-lactamase- and carbapenemase-producing among patients suspected to have surgical site infection at Hospital in Southern Ethiopia.
Materials And Methods: A hospital-based cross-sectional study was conducted on 422 suspected surgical site infections from June 1, 2022 to August 30, 2022 at Hospitals in Southern Ethiopia. Sociodemographic and clinical data were obtained by using a structured questionnaire. Clinical samples (pus, pus aspirates, and wound swabs) were collected aseptically and processed within 30 min by placing the swabs in sterile test tubes containing sterile normal saline (0.5 mL). Samples were cultured on blood and MacConkey agar plates. All positive cultures were characterized by colony morphology, Gram staining, and standard biochemical tests. Antimicrobial sensitivity tests were performed using Kirby Baur disk diffusion on Mueller-Hinton agar. ESBL production was confirmed using a double-disc synergy test (DDST) method. Carbapenemase production was assessed using the modified Hodge test. Logistic regression analysis was used to determine associated factors. A -value < 0.05 were considered statistically significant.
Result: Bacteria belonging to the order were cultured in 23.7% out of 422 patients with suspected surgical wound infection. Of all the isolates, (69 isolates) were the most frequent, with (29/69) followed by (14/69). Of 69 isolates, 66.6 % (46/69) were positive for ESBL production, and 21.7 (15/69) were positive for carbapenemase-producing . The majority of isolates showed sensitivity to meropenem (72.1%); however revealed 63.9% and 70.5% were resistant to gentamicin and ciprofloxacin, respectively. Similarly, a higher resistance rate to cefepime (91.8%), amoxicillin-clavulanic acid (98.4%), ceftriaxone (95.1%), and ceftazidime (91.8%). MDR rate of isolates was 25/61 (41%) among patients suspected for surgical site infection. The Multivariable analysis revealed that length of hospital stay in hospital [AOR = 3.81 (95% CI 2.08-6.95)] remained statistically significant factor associated with surgical site infection due to ESBL producing .
Conclusion: Study results showed the severity of ESBL-producing is critical and CPE is alarming. Meropenem is the most effective antibiotic against the ESBL-producing . MDR rate of isolates was 61 (61%) among patients suspected for surgical site infection. Therefore, antibiotic selection should be based on the results of the culture and sensitivity tests.
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http://dx.doi.org/10.3389/fmicb.2024.1417425 | DOI Listing |
Langenbecks Arch Surg
January 2025
Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University, Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Purpose: The impact of body-cavity depth on open (OLR) and laparoscopic liver resection (LLR) of segment 7 remains unclear. Therefore, we investigated the influence of body-cavity depth at the upper-right portion of the abdomen on LLR and OLR of segment 7.
Methods: In total, 101 patients who underwent segment-7 liver resection over 2010-2023 were included.
Cureus
December 2024
Pathology, Avalon University School of Medicine, Willemstad, CUW.
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally invasive cutaneous sarcoma with a high propensity for recurrence, even following complete surgical excision. DFSP exhibits a low metastatic potential and is characterized by a distinctive honeycomb-like architecture composed of uniformly arranged spindle cells that frequently show CD34 immunostaining. Common surgical approaches include wide local excision (WLE), Mohs micrographic surgery (MMS), and, in severe cases, amputation.
View Article and Find Full Text PDFCureus
December 2024
Department of Pharmacy Practice, Ratnam Institute of Pharmacy, Nellore, IND.
Introduction The success of surgical procedures is becoming more threatened by the advent of multi-drug resistant (MDR) bacterial strains, sometimes known as superbugs. These resistant microorganisms frequently cause post-surgical infections, which raise morbidity, death, and medical expenses. With an emphasis on resistant strains, this seeks to create an antibiogram and a thorough microbiological profile of surgical infections in order to help choose the most effective antimicrobial therapy.
View Article and Find Full Text PDFCureus
December 2024
Department of General Surgery, Ganesh Shankar Vidhyarthi Memorial Medical College, Kanpur, IND.
Background and objective Inguinal hernia in children results from a failure of the processus vaginalis (PV) to close, leading to herniation. Surgical repair is necessary to prevent complications in this patient population. This study aimed to compare the outcomes between laparoscopic herniotomy (LH) and open herniotomy (OH) in pediatric patients with inguinal hernia.
View Article and Find Full Text PDFPrz Gastroenterol
August 2023
Pediatric Department, Hawler Medical University, Erbil, Iraq.
Introduction: Ingestion of foreign bodies is a significant problem among children, which necessitates early intervention and may lead to serious morbidity and even mortality.
Aim: To estimate the pattern of foreign body ingestion among children and identify the role of management and its outcomes in relation to the type and site of foreign bodies.
Material And Methods: Our study was carried out on patients who attended the Emergency Department of the Rapareen Teaching Hospital for Paediatrics in Erbil city and were referred to the Paediatric Gastroenterology Unit during between March 2019 and January 2023.
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