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Galectin-3 depletion tames pro-tumoural microglia and restrains cancer cells growth.
Cancer Lett
June 2024
Instituto de Biomedicina de Sevilla, IBiS/Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain; Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Spain. Electronic address:
Galectin-3 (Gal-3) is a multifunctional protein that plays a pivotal role in the initiation and progression of various central nervous system diseases, including cancer. Although the involvement of Gal-3 in tumour progression, resistance to treatment and immunosuppression has long been studied in different cancer types, mainly outside the central nervous system, its elevated expression in myeloid and glial cells underscores its profound impact on the brain's immune response. In this context, microglia and infiltrating macrophages, the predominant non-cancerous cells within the tumour microenvironment, play critical roles in establishing an immunosuppressive milieu in diverse brain tumours.
View Article and Find Full Text PDFMouse intestinal microbiome modulation by oral administration of a GABA-producing strain.
Microbiol Spectr
January 2024
Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias-Consejo Superior de Investigaciones Científicas (IPLA-CSIC), Paseo Río Linares s/n , Villaviciosa, Asturias, Spain.
The gut microbiome-brain communication signaling has emerged in recent years as a novel target for intervention with the potential to ameliorate some conditions associated with the central nervous system. Hence, probiotics with capacity to produce neurotransmitters, for instance, have come up as appealing alternatives to treat disorders associated with disbalanced neurotransmitters. Herein, we further deep into the effects of administering a gamma-aminobutyric acid (GABA)-producing strain, previously demonstrated to contribute to reduce serum glutamate levels, in the gut microbiome composition and metabolic activity in a mouse model.
View Article and Find Full Text PDFOrally Administered Bifidobacterium adolescentis Diminishes Serum Glutamate Concentration in Mice.
Microbiol Spectr
August 2023
Exosomes Laboratory, Center for Cooperative Research in Biosciences, Basque Research and Technology Alliance, Derio, Spain.
Several studies have described the contribution of glutamate-transforming microbiota to the development of chronic ailments. For instance, the blood concentration of glutamate is higher in some patients with fibromyalgia, chronic fatigue, and pain. Taking advantage of a naturally occurring strain of that is able to transform glutamate in γ-aminobutyric caid (GABA), B.
View Article and Find Full Text PDFBifidobacterium adolescentis as a key member of the human gut microbiota in the production of GABA.
Sci Rep
August 2020
Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11a, 43124, Parma, Italy.
Article Synopsis
- GABA is a key neurotransmitter linked to anxiety and depression, and recent research shows that gut bacteria can produce it, affecting the gut-brain connection.
- Bifidobacterium adolescentis, a type of gut bacteria, is highlighted as a significant GABA producer and is associated with mental health disorders.
- In lab tests with rats, two strains of B. adolescentis were found to increase GABA production, suggesting their potential role in improving gut-brain health.
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