Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations.

NPJ Biofilms Microbiomes

Laboratory of Virology (LIM-52), Department of Infectious Diseases and Tropical Medicine, Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Published: November 2024

The lower female reproductive tract (FRT) hosts a complex microbial environment, including eukaryotic and prokaryotic viruses (the virome), whose roles in health and disease are not fully understood. This review consolidates findings on FRT virome composition, revealing the presence of various viral families and noting significant gaps in knowledge. Understanding interactions between the virome, microbiome, and immune system will provide novel insights for preventing and managing lower genital tract disorders.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589587PMC
http://dx.doi.org/10.1038/s41522-024-00613-6DOI Listing

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