AI Article Synopsis
- * Advances in technology have enhanced our ability to analyze these changes, leading to better understanding of their impact on cancer and potential biomarkers for diagnosis and prognosis.
- * The article reviews key methods used to study these epigenetic alterations in breast cancer, including techniques like ChIP, bisulfite conversion, and next-generation sequencing.
Article Abstract
Epigenetic dysregulation of gene expression is central to breast cancer initiation, progression, and treatment response. These alterations include histone modifications, DNA methylation, and expression of noncoding RNA. Technological advancements have improved our ability to identify histone modifications, DNA methylation patterns and provided critical insights into the epigenetic regulation of gene expression and its role in breast oncogenesis. The epigenetic profiles of healthy and breast cancer tissues revealed several diagnostic and prognostic biomarkers. In this article, we review the methodologies commonly used to study tumor-associated histone modifications and DNA methylation changes in breast cancer, highlighting their principles, applications, and advancements, such as chromatin immunoprecipitation (ChIP), bisulfite conversion of DNA, next-generation sequencing (NGS), and chromatin immunoprecipitation sequencing (ChIP-seq).
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| http://dx.doi.org/10.1007/978-3-031-66686-5_7 | DOI Listing |
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