Epigenetic Modulations by Microbiome in Breast Cancer.

Adv Exp Med Biol

Department of Medical Microbiology and Immunology, University of California Davis School of Medicine, Davis, CA, USA.

Published: November 2024

AI Article Synopsis

  • Recent studies highlight the important role of the microbiome in influencing host physiology and its association with cancer, particularly in modifying the tumor microenvironment.
  • Changes in epigenetic regulation of key cancer-related genes are linked to the onset and progression of breast cancer, with the microbiota playing a role in modulating these epigenetic mechanisms.
  • Understanding the interplay between the microbiome and epigenetics could lead to novel therapeutic strategies for breast cancer treatment.

Article Abstract

Recent studies have identified a critical role of the diverse and dynamic microbiome in modulating various aspects of host physiology and intrinsic processes. However, the altered microbiome has also become a hallmark of cancer, which could influence the tumor microenvironment. Aberrations in epigenetic regulation of tumor suppressors, apoptotic genes, and oncogenes can accentuate breast cancer onset and progression. Interestingly, recent studies have established that the microbiota modulates the epigenetic mechanisms at global and gene-specific levels. While the mechanistic basis is unclear, the cross-talk between the microbiome and epigenetics influences breast cancer trajectory. Here, we review different epigenetic mechanisms of mammalian gene expression and summarize the host-associated microbiota distributed across the human body and their influence on cancer and other disease-related genes. Understanding this complex relationship between epigenetics and the microbiome holds promise for new insights into effective therapeutic strategies for breast cancer patients.

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Source
http://dx.doi.org/10.1007/978-3-031-66686-5_4DOI Listing

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