AI Article Synopsis
- - The study analyzed trends in gabapentin use among infants in neonatal intensive care units (NICUs) from 2005 to 2020, finding that only 85 infants (less than 0.01%) received the drug despite a significant increase of 1,055% in usage over that time.
- - Gabapentin-exposed infants had a lower median birth weight (2,160 g) compared to those who did not receive it (2,498 g), and many were premature or had chronic health issues such as lung disease and drug withdrawal syndrome.
- - The research highlighted concerns about the safety and effectiveness of gabapentin in infants, emphasizing the need for more studies to understand its implications better. *
Article Abstract
Objective: This study aimed to analyze trends in gabapentin use in neonatal intensive care units (NICUs) and examine demographic characteristics, diagnoses, and concomitant medications associated with its use.
Study Design: Cohort study of 987,181 infants hospitalized in the NICU from 2005 to 2020.
Results: Eighty-five infants (<0.01%) received gabapentin. From 2009 to 2020, there was a 1,055% relative increase in gabapentin use ( < 0.01). The median birth weight was 2,160 g (25th, 75th percentiles: 875, 3,080 g) in gabapentin-exposed infants compared with 2,498 g (1,890, 3,210 g) in unexposed infants ( < 0.001). Over half (55%) of infants receiving gabapentin were born prematurely, 54% ( = 45) had chronic lung disease, 46% ( = 39) had gastrostomy tubes, and 34% ( = 29) had drug withdrawal syndrome; 49% ( = 42) and 27% ( = 23) received opioids and benzodiazepines, respectively.
Conclusion: Use of gabapentin was rare but increased over time despite limited research on its safety and efficacy in infants, illuminating the need for further studies.
Key Points: · Gabapentin safety in infants is not well understood.. · Gabapentin use increased despite limited safety research.. · Further studies on gabapentin use in infants are needed..
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/a-2451-9925 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!