Hemodynamic changes of arteriovenous malformation and endovascular embolization.

Neuroradiol J

Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, China.

Published: November 2024

AI Article Synopsis

  • A meta-analysis was conducted to investigate the hemodynamic changes caused by arteriovenous malformations (AVM) and their embolization, including a comprehensive literature review until November 2023.
  • The analysis included 13 studies, which revealed that arterial diameter and flow velocity positively correlated with cerebral blood flow, while pressure differences varied based on the size of the AVM nidus.
  • Embolization sessions showed a negative correlation with blood flow, and the relationships between arterial pressure, peri-AVM perfusion, and occlusion percentages were found to be linear for medium and small AVMs but nonlinear for large AVMs.

Article Abstract

To analyze the hemodynamic changes caused by arteriovenous malformation (AVM) and AVM embolization through a meta-analysis of the existing literature. Search for relevant studies on PubMed/Medline until November 7, 2023, and further screen the bibliographies of relevant studies to ensure comprehensive search. According to the PRISMA guidelines, manuscripts were selected to provide local hemodynamic information on AVM arterial feeders and drainage veins. A total of 13 studies were included in the final analysis. The diameter of the supplying artery (y = 0.002x + 2.24, R = 0.99) and flow velocity (y = 0.09x + 54.55, R = 0.92) had a positive linear relationship with cerebral blood flow. The pressure difference through the small AVM nidus was higher than that in the large AVM, with values of (y = -12.23x + 101.39, R = 0.96). There was a negative linear correlation between the sessions of AVM embolization and blood flow (1 session: y = -150.7x + 564.97, R = 0.98 and 4 sessions: y = -118.81x + 750.07, R = 0.99). There was a positive linear relationship between the increase in arterial pressure, peri-AVM parenchymal perfusion, and the percentage of occlusion in the medium-sized AVMs. However, this correlation was a nonlinear relationship between elevated arterial pressure, peri-AVM parenchymal perfusion, and the percentage of large AVM occlusion. The hemodynamic changes of AVM (in the feeding arteries, compartments of AVM, and draining veins) follow a linear relationship. The impact of embolization on hemodynamics in medium and small AVMs follows a linear relationship. The impact of embolization of large AVMs on hemodynamics follows a nonlinear relationship.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590089PMC
http://dx.doi.org/10.1177/19714009241303056DOI Listing

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