Preterm birth remains the leading cause of infant morbidity and mortality worldwide. Efforts aimed at reducing preterm birth rates have largely focused on mitigating risks in those who have already experienced a preterm delivery. One intervention, the placement of a cervical cerclage, has been shown to reduce the risk of subsequent preterm delivery in the appropriate candidate. However, a cerclage does not mitigate the risk of premature preterm rupture of membranes (PPROM). PPROM is a significant contributor to the incidence of preterm births and can occur with a cerclage in place. Many studies have examined the outcomes associated with immediate vs delayed cerclage removal following PPROM with inconsistent results. In this expert review, we summarize the characteristics of the studies examining timing of cerclage removal following PPROM (Table 1), and current international guidelines (Table 2). In the absence of labor, infection, cervical laceration or vaginal bleeding, we recommend that cervical cerclage remain in situ following PPROM until 32-34 weeks gestation.
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http://dx.doi.org/10.1016/j.ajogmf.2024.101569 | DOI Listing |
BMC Pregnancy Childbirth
December 2024
Ultrasound Department, Ganzhou Maternal and Child Health Hospital, No. 25, Nankang Road, Zhanggong District, Ganzhou City, Jiangxi Province, 341000, China.
Objective: To study the implementation value of abdominal B-ultrasound combined with cervical cerclage in the prevention and treatment of recurrent late abortion.
Methods: From October 2020 to December 2023, 196 pregnant patients who had a history of late abortions at our institution were chosen. They were divided into groups based on the treatments used.
Am J Perinatol
December 2024
Obstetrics and Gynecology, Duke University Hospital, Durham, United States.
Objective: A single center randomized trial showed improved latency with use of indomethacin and cefazolin (I/C) during and following exam-indicated cerclage (EIC). The same center recently published a pre/post comparison demonstrating similar results. This research aimed to validate the protocol in a different setting.
View Article and Find Full Text PDFFront Physiol
November 2024
Department of Obstetrics and Gynaecology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China.
Background: Preterm birth is a significant concern in multiple pregnancies, warranting effective strategies to improve outcomes. Delaying delivery of the second fetus is crucial for reducing perinatal mortality rates.
Case Presentation: In a dichorionic diamniotic twin pregnancy, one fetus experienced premature rupture of membranes (PROM) at 16+6 weeks gestation.
EClinicalMedicine
December 2024
Department of Obstetrics and Gynaecology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
Background: Previous spontaneous preterm birth (sPTB) is a strong risk indicator for recurrent preterm birth (PTB). Cervical cerclage is an accepted intervention to prevent recurrent PTB in high risk patients. Cervical pessary might be a less invasive alternative.
View Article and Find Full Text PDFZ Geburtshilfe Neonatol
December 2024
Frauenheilkunde und Geburtshilfe, Medizinische Universitätsklinik, Universitätsklinikum Freiburg, Freiburg im Breisgau, Germany.
Introduction: The aim of the study was to evaluate the effectiveness of cerclage in women with previous late miscarriages or premature births. The primary aim was to prolong pregnancy and achieve a term delivery. Secondarily, it was investigated whether an intervention after an early pathological 75-g-oGTT result influences these endpoints.
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