Age-related losses in executive control are widely assumed to contribute to prospective memory (PM) lapses in late adulthood, but to date, this assumption has gained only inconsistent support from lab-based studies. The present study tested whether age indirectly affects PM via (1) individual differences in specific executive control operations (a parallel mediated model), or (2) a serially mediated model, with processing speed as the first mediator. Older adults (= 166) completed four measures of PM that had higher ecological validity than standard lab-based paradigms, as well as measures of executive function and other cognitive abilities. The results showed that, although age was a significant predictor of reduced performance on three of the PM measures, particularly time-based tasks, these negative age associations were only slightly diminished when executive functions were controlled for. Performance on the PM task with the greatest ecological validity (MEMO) was independent of age and measures of executive function but positively related to both learning and retention. Processing speed was a poor predictor of PM performance on all measures (accounting for between 0% and 4% of variance). Taken together, these results highlight the need for circumspection in generalising the role of executive control in age-related prospective memory performance.
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http://dx.doi.org/10.1080/09658211.2024.2431672 | DOI Listing |
BMC Med
December 2024
Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology & Population Health, London, School of Hygiene and Tropical Medicine, London, UK.
Background: Direct oral anticoagulants (DOACs) have been reported to be associated with a higher risk of mortality compared with an older alternative, warfarin using primary care data in the United Kingdom (UK). However, other studies observed contradictory findings. We therefore aimed to investigate the association between mortality and warfarin, compared with DOACs.
View Article and Find Full Text PDFNeurobiol Aging
December 2024
Department of Psychology, Northwestern University, Evanston, IL, USA; Department of Psychology, Florida State University, Tallahassee, FL, USA; University of Illinois Urbana-Champaign, Champaign, IL, USA.
Healthy aging is associated with cognitive decline across multiple domains, including executive function, memory, and attention. These cognitive changes can often influence an individual's ability to function and quality of life. However, the degree to which individuals experience cognitive decline, as well as the trajectory of these changes, exhibits wide variability across people.
View Article and Find Full Text PDFAppl Neuropsychol Child
December 2024
Institute on Development and Disability, Department of Pediatrics, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Executive functions (EF) affect child competencies across domains in early childhood. Thus, this study examined: 1) the EF differences between young children with global developmental delays (GDD) and those with typical development (TD); 2) the relationship between mastery motivation (MM) and EF; 3) the association between developmental abilities and EF in both groups. Participants included 26 mother-child dyads of preschoolers with GDD (age 24-55 months) and 26 sex- and mental-age-matched dyads of TD preschoolers (age 15-29 months).
View Article and Find Full Text PDFTrials
December 2024
School of Medicine Depts of Pediatrics, Neurology and Pharmacology, Children's Hospital Colorado/University of Colorado, 12800 E 19th, MS8102, Aurora, CO, 80045, USA.
Introduction: The clinical, research and advocacy communities for Rett syndrome are striving to achieve clinical trial readiness, including having fit-for-purpose clinical outcome assessments. This study aimed to (1) describe psychometric properties of clinical outcome assessment for Rett syndrome and (2) identify what is needed to ensure that fit-for-purpose clinical outcome assessments are available for clinical trials.
Methods: Clinical outcome assessments for the top 10 priority domains identified in the Voice of the Patient Report for Rett syndrome were compiled and available psychometric data were extracted.
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