AI Article Synopsis
- The review emphasizes the critical role of lipids in acute myeloid leukemia (AML) processes, particularly how they affect leukemic stem cells (LSCs) and their metabolism.* -
- Recent studies indicate that lipid metabolism supports LSC function and AML survival through energy production, membrane composition, and various signaling pathways, including the impact of metabolic flexibility on treatment responses.* -
- The findings suggest that further research into lipid metabolism could lead to innovative treatments targeting lipids in AML, improving patient outcomes by addressing the complex regulation and use of lipids in the disease.*
Article Abstract
Purpose Of Review: The aim of this review is to highlight the importance of lipids' intricate and interwoven role in mediating diverse acute myeloid leukemia (AML) processes, as well as potentially novel lipid targeting strategies. This review will focus on new studies of lipid metabolism in human leukemia, particularly highlighting work in leukemic stem cells (LSCs), where lipids were assessed directly as a metabolite.
Recent Findings: Lipid metabolism is essential to support LSC function and AML survival through diverse mechanisms including supporting energy production, membrane composition, signaling pathways, and ferroptosis. Recent work has highlighted the role of lipid rewiring in metabolic plasticity which can underlie therapy response, the impact of cellular and genetic heterogeneity in AML on lipid metabolism, and the discovery of noncanonical roles of lipid related proteins in AML.
Summary: Recent findings around lipid metabolism clearly demonstrates their importance to our understanding and therapeutic targeting of AML. We have only begun to unravel the regulation and utilization of lipids in this disease. Further, understanding the layered dynamics of lipid homeostasis could provide novel opportunities to target lipid metabolism in AML and LSCs with the potential of improving outcomes for patients with AML.
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| http://dx.doi.org/10.1097/MOH.0000000000000853 | DOI Listing |
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