Background: Tuberculosis remains a major global public health problem, affecting millions of people every year, including children. At the same time, depressive disorders are among the most common mental disorders in children and adolescents, significantly influencing their quality of life and development. The intersection between these two pathologies-tuberculosis and depressive disorders-in pediatric patients raises complex clinical challenges that require effective identification and intervention strategies.
Materials And Methods: A total sample of 190 patients aged between 7 and 18 years who presented to Galati "St. Spiridon" Pneumophthisiology Hospital between January 2019 and December 2021 was used.
Objective: The main objective of this paper is to achieve a predictive score of depressive disorders in pediatric patients diagnosed with a form of tuberculosis. This score is particularly important because it helps to identify and treat early depressive disorders in children previously diagnosed with tuberculosis, resulting in increased compliance with anti-tuberculosis treatment, decreased dropout rate, and an optimal duration of hospitalization and surveillance, which positively influences the incidence of tuberculosis.
Results: The final score is determined by a rating of a total of 9 points: if the value is below 4 points, there is a minor risk of affective disorders; if the value is between 4 and 6 points, there is a medium risk of affective disorders; if the value is above 6 points, there is a severe risk of affective disorders.
Conclusions: A detailed clinical assessment, the usage of screening tools, long-term monitoring, multidisciplinary interventions, and family support are essential to ensure an effective management and to improve the life quality of these children.
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http://dx.doi.org/10.3390/clinpract14060187 | DOI Listing |
JAMA Psychiatry
January 2025
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Importance: Mania/hypomania is the pathognomonic feature of bipolar disorder (BD). As BD is often misdiagnosed as major depressive disorder (MDD), replicable neural markers of mania/hypomania risk are needed for earlier BD diagnosis and pathophysiological treatment development.
Objective: To replicate the previously reported positive association between left ventrolateral prefrontal cortex (vlPFC) activity during reward expectancy (RE) and mania/hypomania risk, to explore the effect of MDD history on this association, and to compare RE-related left vlPFC activity in individuals with and at risk of BD.
Autism
January 2025
The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
This study aimed to examine whether an acceptance and commitment therapy (ACT)-based parenting program, incorporating topics of emotional and stress management, parenting skills training, autism-related education, and self-care learning, could be successfully implemented, well-received, and beneficial for parents of children with autism. We randomly assigned 40 parents to either participate in the eight-session ACT-based parenting program or receive usual care only. The program was found to be feasible, with many parents willing to participate and complete the sessions.
View Article and Find Full Text PDFFood Funct
January 2025
Hubei Provincial Engineering and Technology Research Center for Food Ingredients, Hubei University of Arts and Science, Xiangyang, Hubei, PR China.
The gut microbiome has emerged as a growing focus of research and public health interest, leading to the frequent exploration of probiotic dietary supplements as potential treatments for various disorders, such as anxiety and depression. In the present report, changes in inflammation and microbiome composition were assessed in model mice exhibiting depressive-like behaviors that were exposed to the probiotic HBUAS52074. It was found that HBUAS52074 alleviated the severity of depressive-like behaviors while increasing serum 5-HT concentrations.
View Article and Find Full Text PDFPsychopharmacol Bull
January 2025
Oslin, MD, Veterans Integrated Service Network 4, Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center and Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Background: Immunologic measures have been studied as predictors of who will respond to standard antidepressants. Two previous, small studies of pretreatment leukocyte mRNA expression levels of the cytokines macrophage migration inhibitory factor (MIF) and interleukin 1-beta (IL1-β) identified antidepressant treatment responders.
Methods: We tested these findings in 1,299 patients from the PRIME Care study, a multi-center pharmacogenetic depression treatment trial.
Pers Individ Dif
February 2025
University of Delaware, Department of Psychological and Brain Sciences.
There is growing interest in understanding whether, and under what circumstances, depression confers risk for violence perpetration. To address these questions, we examined whether major depressive disorder (MDD) symptoms correlated with violence perpetration beyond co-occurring externalizing psychopathology, and whether individual differences in reward and emotional reactivity modified depression-violence associations. In a sample of 480 community adults ( =32.
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