Background & Objective: Association of multiple coronary arterial microfistulae and myocardial bridge together with concentric diffuse hypertrophic obstructive cardiomyopathy is considerably rare and we aim to highlight a similar unusual but clinically significant association in a young adult female patient with hypertrophic cardiomyopathy, presenting with progressively worsening angina on exertion.
Case Findings: A young 38-year-old female presented to the cardiology clinic of our institute with complaints of angina on exertion New York Heart Association (NYHA) class III for 2 years. An electrocardiogram showed left ventricular enlargement and echocardiography showed diffuse hypertrophic obstructive cardiomyopathy with the systolic anterior motion of the mitral valve and left ventricular outflow tract gradient of 40 mm Hg on Valsalva. CT coronary angiography revealed a diffuse concentric hypertrophic left ventricular myocardium with no regional wall motion abnormality, a mid-left anterior descending artery myocardial bridge, multiple coronary arterial microfistulae from distal left anterior descending (LAD) and right coronary artery (RCA) emptying to the right ventricle and dilated pulmonary artery trunk.
Conclusion: In patients with hypertrophic obstructive cardiomyopathy, angina can be rarely due to coronary artery fistula and or myocardial bridge in addition to myocardial perfusion mismatch owing to hypertrophy or a combination of all. CT coronary angiography seems to be the ideal first noninvasive modality for screening and pre-intervention planning.
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http://dx.doi.org/10.7417/CT.2024.5140 | DOI Listing |
Sci Rep
December 2024
Auckland Bioengineering Institute, The University of Auckland, Auckland, New Zealand.
Cardiac sex-difference functional studies have centred on measurements of twitch force and Ca dynamics. The energy expenditures from these two cellular processes: activation (Ca handling) and contraction (cross-bridge cycling), have not been assessed, and compared, between sexes. Whole-heart studies measuring oxygen consumption do not directly measure the energy expenditure of these activation-contraction processes.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
December 2024
3rd Department of Cardiology, "Sotiria" Chest Diseases Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Hypertrophic cardiomyopathy (HCM) is a complex and heterogeneous cardiac disorder, often complicated by cardiogenic shock, a life-threatening condition marked by severe cardiac output failure. Managing cardiogenic shock in HCM patients presents unique challenges due to the distinct pathophysiology of the disease, which includes dynamic left ventricular outflow tract obstruction, diastolic dysfunction, and myocardial ischemia. This review discusses current and emerging therapeutic strategies tailored to address the complexities of HCM-associated cardiogenic shock and other diseases with similar pathophysiology that provoke left ventricular outflow tract obstruction.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
December 2024
Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, China.
Objectives: To investigate the correlation of serum levels of bridging integrating factor 1 (BIN1) with acute myocardial infarction (AMI) and Killip class of the patients.
Methods: We retrospectively collected the data from 94 patients with AMI and 30 healthy individuals for analysis of the correlations of serum BIN1 levels with Killip class, TIMI scores, and neutrophil-to-lymphocyte ratio (NLR). We also assessed the diagnostic value of BIN1 combined with NLR for AMI.
Methods Mol Biol
December 2024
Manaaki Manawa - The Centre for Heart Research and the Department of Physiology, University of Auckland, Auckland, New Zealand.
The use of large animals in research provides a unique bridge between preclinical findings and clinical relevance, offering a valuable perspective for advancing our understanding of the complexities of heart failure. Multiple models of heart failure have been established with advantages and limitations of each model. Many insights have been gained from these models for understanding both pathophysiological mechanisms and therapeutic interventions for heart failure.
View Article and Find Full Text PDFEur Heart J Case Rep
December 2024
Department of Anesthesiology, Center for Clinical and Translational Research, Helios University Hospital Wuppertal, Heusnerstraße 40, 42283 Wuppertal, Germany.
Background: Initially conceptualized as a bridge to heart transplantation, the left ventricular assist device (LVAD) has become an important option for improving survival in patients with severe heart failure and poor prognosis.
Case Summary: We report the case of a patient suffering from severe chronic heart failure, complicated by ST-elevation myocardial infarction due to left main coronary artery stenosis (NYHA IV, INTERMACS profile 1). Despite support with veno-arterial extracorporeal membrane oxygenation, inotropes, and catecholamine therapy, the patient's cardiac function did not recover sufficiently.
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