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Time-dependent changes in medial meniscus kinematics and attachment strength after anterior root injury and repair in a large animal model. | LitMetric

AI Article Synopsis

  • - This study examined the effects of removing the medial meniscus anterior attachment in Yucatan minipigs, comparing outcomes between an injury group and a repair group, with the contralateral knee serving as an intact control.
  • - Findings revealed significant meniscus extrusion following injury, with measurements showing a decrease over time but still higher than the intact condition; attachment tensile testing showed increased elongation after injury that partially improved after 6 months.
  • - The results indicated that meniscus injury leads to cartilage wear over time, emphasizing the importance of understanding the meniscus's role and material properties during joint injury and repair for overall joint health.

Article Abstract

This study investigated joint kinematics and attachment tensile mechanics following resection of the medial meniscus anterior attachment. A secondary objective investigated the repair of the attachment. Yucatan minipigs underwent unilateral surgery for either Injury (en bloc) resection of the anterior attachment of the insertional ligament, (a portion of the cranial medial meniscotibial ligament) or Repair (immediate repair with a suture anchor), with the contralateral knee as Intact control. Evaluation at 6 weeks and 6 months included joint kinematics measured from MRI acquired under knee compression and tensile testing of the attachment. Injury resulted in large levels of meniscus extrusion, despite the development of a fibrovascular scar. At 6 weeks, the meniscus extruded 1.95 mm more than Intact; at 6 months, this extrusion was reduced to 0.77 mm. Under an applied 1× body weight load, the meniscus further extruded and was not different with treatment or time. During attachment tensile testing, elongation was 0.6 mm for Intact, following Injury, elongation was 2.7 mm at 6 weeks and was partially restored to 1.5 mm at 6 months. Despite this, the cartilage wear worsened over time. Repair was inadequate to avoid the extrusion or cartilage wear seen in the injury group at 6 weeks, so it was not continued for the 6-month group. This study demonstrates that while meniscus injury is useful to study cartilage degeneration, a holistic consideration of the role of the meniscus itself, including its changing material properties and its impact on joint mechanics during injury, repair, and rehabilitation, are key factors contributing to overall joint health.

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Source
http://dx.doi.org/10.1002/jor.26022DOI Listing

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