Thioctic acid shield against lipopolysaccharide depression and endoplasmic reticulum stress: GR7M/Homer/ATF6 signaling.

Endoplasmic reticulum stress triggers neuronal unfolded protein accumulation, contributing to the pathophysiology of depression psychiatric illnesses. The brain-derived neurotrophic factor (), metabotropic glutamate receptor type 7 (), phosphoinisitol kinase-3 (), serine/threonine kinase 1 () and may afford an important signaling pathways in LPS induced depression rat model. Herein, thioctic acid, Burdock and propolis therapeutic index on lipopolysaccharide (LPS)-induced depression was monitored. signaling pathways also opened a novel avenue in the integration of synaptic neurotransmission. The aforementioned treatments elevated GR7M/BDNF/GABA gene expression meanwhile decreased reactive oxygen species generation (Malondialdehyde/glutathione reductase/Total antioxidant capacity) and reduced the expression of post LPS elevation. Thioctic acid, propolis and Burdock are prospective therapeutic agents via - signaling pathways in LPS-induced depression.