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Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease.
J Pharmacol Toxicol Methods
January 2025
Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:
Background: Upadacitinib is a selective Janus kinase (JAK) 1 inhibitor approved by the Food and Drug Administration for the treatment of moderate-to-severe inflammatory bowel disease (IBD). We aimed to establish and validate a method for determining Upadacitinib in patients with IBD by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.
Methods: The mobile phase was 0.
The Moderating Effect of Peer Attachment on Associations Between Children's and Adolescents' Cyberbullying Victimization, Bystanding, and Depressive Symptoms.
Int J Environ Res Public Health
December 2024
Department of Psychology, Indiana State University, Terre Haute, IN 47809, USA.
The primary objective of this short-term longitudinal study was to investigate how age groups affect the relationships between cyberbullying victimization, bystanding, and depression among a convenience sample of students across different educational levels; there was a total of 234 elementary school students (fourth and fifth graders), 363 middle school students (sixth to eighth graders), and 341 high school students (ninth to twelfth graders) from the United States who completed self-reported questionnaires on cyberbullying, depression, and peer attachment during 2020. Additionally, this study examined whether peer attachment acted as a moderator in these relationships. The results revealed that strong peer attachment significantly moderated the connections between cyberbullying involvement and depression, as measured six months later, with particularly pronounced effects among middle school students.
View Article and Find Full Text PDFChitosan and ibuprofen grafted electrospun polylactic acid/gelatin membrane mitigates inflammatory response.
Biomed Mater
January 2025
Zhejiang University School of Medicine, 1367 West Wenyi Rd, Hangzhou, 310058, CHINA.
Electrospun membranes with biomimetic fibrous structures and high specific surfaces benefit cell proliferation and tissue regeneration but are prone to cause chronic inflammation and foreign body response (FBR). To solve these problems, we herein report an approach to functionalize electrospun membranes with antibacterial and anti-inflammatory components to modulate inflammatory responses and improve implantation outcomes. Specifically, electrospun polylactic acid (PLA)/gelatin (Gel) fibers were grafted with chitosan (CS) and ibuprofen (IBU) via carbodiimide chemistry.
View Article and Find Full Text PDF3D-Printed PCL Scaffolds Loaded with bFGF and BMSCs Enhance Tendon-Bone Healing in Rat Rotator Cuff Tears by Immunomodulation and Osteogenesis Promotion.
ACS Biomater Sci Eng
January 2025
Department of Orthopedics, Suzhou Wujiang District Hospital of Traditional Chinese Medicine (Suzhou Wujiang District Second People's Hospital), Suzhou 215200, China.
Rotator cuff tears are the most common conditions in sports medicine and attract increasing attention. Scar tissue healing at the tendon-bone interface results in a high rate of retears, making it a major challenge to enhance the healing of the rotator cuff tendon-bone interface. Biomaterials currently employed for tendon-bone healing in rotator cuff tears still exhibit limited efficacy.
View Article and Find Full Text PDFA national survey on Thai medical students' attitudes towards abortion and their confidence in providing abortion services following the amendment to abortion law.
Eur J Obstet Gynecol Reprod Biol X
March 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Thailand.
Objectives: This study aimed to evaluate medical students' attitudes towards abortion and their confidence in providing abortion services in the future.
Material And Methods: A national cross-sectional online survey was conducted among fifth and sixth-year medical students from 10 Thai universities. A self-administered questionnaire assessed their knowledge, attitudes, and confidence regarding abortion services.
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