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Oxia Planum, Mars, is the future landing site of the ExoMars rover mission, which will search for preserved biosignatures in a phyllosilicate-bearing unit. Overlying the mission-important phyllosilicate-bearing rocks is a dark, capping unit-known here as the Low albedo, Thin, Resistant (LTR) unit-which may have protected the phyllosilicate-bearing unit over geologic time from solar insolation and radiation. However, little is known about the origin of the LTR unit. Here, we map the LTR unit and investigate its distribution and morphology across 50,000 km using a variety of orbital remote sensing data sets. The characteristics of the LTR unit include draping palaeo-topographic surfaces, deposition over a wide elevation range, and a consistent vertical thickness that can be best explained by airfall deposition including a primary or reworked volcanic palaeo-ashfall. Previous research suggests that the LTR unit was not significantly buried, and we find it to be preferentially preserved with a high mechanical strength in discrete deposits representing palaeo-topographic lows. We suggest this could be attributed to localized cementation via upwelling groundwater. This scenario suggests that most of the phyllosilicate-bearing exposures may not have been protected over geologic time, as the uncemented LTR sediment would have easily been removed by erosion. However, our observations indicate that the scarped margins of the LTR unit deposits probably exposed regions of the once protected phyllosilicate-bearing unit. These areas could be key science targets for the ExoMars rover mission.
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http://dx.doi.org/10.1029/2024JE008527 | DOI Listing |
Int J Mycobacteriol
October 2024
Research Unit, Haji Hospital, Surabaya.
Background: All-oral regimens, including bedaquiline, are now standard in shorter treatment regimens (STRs) for multidrug-resistant tuberculosis (MDR-TB). Resistance or intolerance to drugs in STR often necessitates a switch to longer treatment regimens (LTRs). This study aims to identify the factors associated with this transition in MDR-TB patients.
View Article and Find Full Text PDFOxia Planum, Mars, is the future landing site of the ExoMars rover mission, which will search for preserved biosignatures in a phyllosilicate-bearing unit. Overlying the mission-important phyllosilicate-bearing rocks is a dark, capping unit-known here as the Low albedo, Thin, Resistant (LTR) unit-which may have protected the phyllosilicate-bearing unit over geologic time from solar insolation and radiation. However, little is known about the origin of the LTR unit.
View Article and Find Full Text PDFCureus
October 2024
AIDS, TB, and Malaria, Common Management Unit, Islamabad, PAK.
Background The currently recommended treatment regimens for multidrug-resistant tuberculosis (MDR-TB) are complex, costly, prolonged (lasting at least 20 months), and often poorly tolerated. The objective of this study was to evaluate the effectiveness of the shorter treatment regimen (STR) for treating patients with MDR-TB in Khyber Pakhtunkhwa. Methodology The present study was a case series conducted at the Programmatic Management of Drug Resistant TB Unit, Lady Reading Hospital (PMDT-LRH), Khyber Pakhtunkhwa, Pakistan.
View Article and Find Full Text PDFVirol J
October 2024
Pathology and Clinical Pathology Department, Faculty of Veterinary Medicine, New Valley University, The New Valley Governorate, Egypt.
Background: Reticuloendotheliosis virus (REV) is an oncogenic immunosuppressive retrovirus that infects different kinds of avian species; posing significant economic losses to the poultry industry worldwide.
Methods: In Egypt, there is an unidentified disease associated with the runting-stunting syndrome with neoplasia, suspected to be REV, that has been continuously monitored in several breeder flocks. To diagnose and analyze REV by cell cultures, enzyme-linked immunosorbent assay (ELISA), histopathological investigation, the polymerase chain reaction (PCR) test, and sequencing analysis, 200 blood samples, and 50 tissue specimens were collected.
Anal Chem
October 2024
Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bengaluru, 560064 Karnataka, India.
The noncanonical conformations within the genomes of viral pathogens is of significant diagnostic value, due to their unique secondary structures and interactions with specific fluorogenic molecules. In particular, adaptation of the G-quadruplex (GQ) conformation by the specific gene sequence leads to distinct topological features, resulting in unique binding sites that are crucial for the selective recognition of human immunodeficiency virus (HIV) by small molecules. Leveraging the selective fluorescence response of a benzobisthiazole-based fluorogenic probe to the LTR-III GQ target, we developed a GQ-based diagnostic platform for HIV detection.
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