Cureus
General Medicine, Dr. D Y Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth (Deemed to be University), Pune, IND.
Published: October 2024
Heat exhaustion progresses to heat stroke and then on to heatstroke encephalopathy, a serious illness. Extreme hyperthermia (over 40.5 °C), central nervous system failure, multiorgan dysfunction, and hypovolemic shock are the hallmarks of the clinical presentation of heatstroke. A 27-year-old male was presented to the causality with loss of consciousness followed by altered sensorium while working outdoors (outside temperature was 40°C), low blood pressure (70/50 mmHg), hyperthermia (41°C), tachycardia, focal seizures (1 episode), hypovolemic shock. At presentation, the Glasgow Coma Scale was E1V1M1, and he was intubated, moved to the intensive care unit, and monitored closely. He was treated with antibiotics, anticonvulsants, intravenous fluids, vasopressor supports, and body surface cooling methods. The hematological investigations showed thrombocytopenia, deranged liver, and renal function tests. On day 1, magnetic resonance imaging (MRI) of the brain showed normal study. As the patient's neurological status showed no improvement MRI of the brain was repeated on day 8 which showed restricted diffusion with hyperintensities involving bilateral caudate nuclei, anterior aspects of bilateral putamen, and insular cortex, suggesting to rule out infective encephalopathy. Based on history, clinical presentation, laboratory, and radiological investigations this case has been diagnosed as exertional heatstroke encephalopathy.
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http://dx.doi.org/10.7759/cureus.72257 | DOI Listing |
Front Biosci (Schol Ed)
December 2024
Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
Background: Disruptions in proteostasis are recognized as key drivers in cerebro- and cardiovascular disease progression. Heat shock proteins (HSPs), essential for maintaining protein stability and cellular homeostasis, are pivotal in neuroperotection. Consequently, deepening the understanding the role of HSPs in ischemic stroke (IS) risk is crucial for identifying novel therapeutic targets and advancing neuroprotective strategies.
View Article and Find Full Text PDFJ Integr Neurosci
December 2024
Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
Background: Heat shock proteins (HSPs) play a critical role in the molecular mechanisms of ischemic stroke (IS). A possible role for HSP40 family proteins in atherosclerosis progression has already been revealed; however, to date, molecular genetic studies on the involvement of genes encoding proteins of the HSP40 family in IS have not yet been carried out.
Aim: We sought to determine whether nine single nucleotide polymorphisms (SNPs) in genes encoding HSP40 family proteins (, , , , and ) are associated with the risk and clinical features of IS.
Front Mol Neurosci
December 2024
Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, Kursk, Russia.
As many proteins prioritize functionality over constancy of structure, a proteome is the shortest stave in the Liebig's barrel of cell sustainability. In this regard, both prokaryotes and eukaryotes possess abundant machinery supporting the quality of the proteome in healthy and stressful conditions. This machinery, namely chaperones, assists in folding, refolding, and the utilization of client proteins.
View Article and Find Full Text PDFCureus
October 2024
General Medicine, Dr. D Y Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth (Deemed to be University), Pune, IND.
Heat exhaustion progresses to heat stroke and then on to heatstroke encephalopathy, a serious illness. Extreme hyperthermia (over 40.5 °C), central nervous system failure, multiorgan dysfunction, and hypovolemic shock are the hallmarks of the clinical presentation of heatstroke.
View Article and Find Full Text PDFBiomed Pharmacother
November 2024
Department of Tropical Medicine, College of Military Preventive Medicine, Army Medical University, Chongqing, China; Key Laboratory of Extreme Environmental Medicine, Ministry of Education of China, Army Medical University, Chongqing, China. Electronic address:
Heatstroke is a condition caused by overheating of the body that leads to severe central nervous system dysfunction. Although there have been numerous studies on the pathological process of heatstroke, effective treatment methods are lacking. Astragaloside IV can protect the brain from inflammation and brain damage in various inflammation-related diseases, but it has not yet been used clinically for the treatment of heatstroke.
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