AI Article Synopsis
- The study investigates the relationship between lipid metabolism and hyperuricemia (HUA) in middle-aged and elderly Chinese individuals, identifying 123 lipids linked to uric acid levels.
- The prevalence of HUA in the sampled population was found to be 10.4%, with specific lipid types like diacylglycerols and phosphatidylcholines showing a positive association with HUA risk.
- Dietary intake, such as aquatic products increasing HUA risk and dairy reducing it, alongside the mediation role of retinol-binding protein 4 (RBP4), highlights the complex interplay between lipids, diet, and HUA.
Article Abstract
Unlabelled: Little is known about the links of disturbed lipid metabolism with hyperuricemia (HUA). We aimed to investigate the associations of lipidomic profiles with uric acid (UA)/HUA and their modifying factors in middle-aged and elderly Chinese. A total of 350 lipids were quantified in 2247 community-based Chinese aged 50-70 years by high-coverage targeted lipidomics. HUA was defined by plasma UA > 420 μmol/L in men or > 360 μmol/L in women. The prevalence of HUA in this population was 10.4%. After multivariable adjustment including BMI and lifestyle, 123 lipids were significantly associated with UA, predominantly glycerolipids (GLs) and glycerophospholipids (GPs). Specifically, diacylglycerol [DAG (16:0/22:5), DAG (16:0/22:6), DAG (18:1/20:5), DAG (18:1/22:6)], phosphatidylcholine [PC (16:0/20:5)), and triacylglycerol (TAG (53:0)] were the most significant lipid signatures positively associated with HUA risk, while lysophosphatidylcholine (LPC (20:2)) was inversely associated with HUA risk ( < 0.05). Network analysis also showed a positive association between TAGs/PCs/DAGs contained module and HUA risk ( < 0.01). Notably, HUA-related lipids were associated with de novo lipogenesis fatty acids, especially 16:1n-7 (Spearman correlation coefficients = 0.32-0.41, < 0.001). Reduced rank regression showed that increased aquatic products intake was correlated to elevated HUA risk and HUA-associated lipids; while high dairy consumption was correlated with low level of HUA-associated lipids (|factor loadings| ≥ 0.2). Moreover, mediation analyses suggested that the lipid-HUA associations were partially mediated by retinol-binding protein 4 (RBP4, mediation proportion 5-14%), an adipokine linked with dyslipidemia and insulin resistance. In conclusion, disturbed specific metabolisms of GLs and GPs were associated with high prevalent HUA, partially mediated by RBP4 and/or influenced by certain dietary factors.
Supplementary Information: The online version contains supplementary material available at 10.1007/s43657-024-00157-x.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584823 | PMC |
| http://dx.doi.org/10.1007/s43657-024-00157-x | DOI Listing |
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